Protein Wnt-11 (WNT11) ELISA Kit for Human

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

WNT11: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: cytoplasm; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: frizzled binding; GTPase activator activity; protein binding; protein kinase activator activity

Biological Process: activation of protein kinase activity; adrenal gland development; artery morphogenesis; bone mineralization; cell fate commitment; cloacal septation; convergent extension involved in axis elongation; embryonic skeletal system development; epithelial to mesenchymal transition; maintenance of epithelial cell polarity; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell migration; negative regulation of transcription, DNA-dependent; neuron differentiation; notochord morphogenesis; osteoblast differentiation; palate development; paraxial mesoderm formation; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of stress fiber formation; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta2 production; protein amino acid phosphorylation; response to nutrient levels; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway; Wnt signaling pathway