Activin Receptor Type-2a (ACVR2A) ELISA Kit for Rat

ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily

Chromosomal Location of Human Ortholog: 3q12

Cellular Component: activin receptor complex; cell surface; cytoplasm; integral component of membrane; receptor complex

Molecular Function: activin binding; activin receptor activity, type II; activin-activated receptor activity; ATP binding; coreceptor activity; growth factor binding; metal ion binding; PDZ domain binding; protein self-association; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; anterior/posterior pattern specification; BMP signaling pathway; determination of left/right symmetry; embryonic skeletal system development; gastrulation with mouth forming second; male gonad development; mesoderm development; penile erection; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of osteoblast differentiation; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of BMP signaling pathway; regulation of nitric-oxide synthase activity; regulation of signal transduction; response to organic substance; Sertoli cell proliferation; sperm ejaculation; spermatogenesis