Apolipoprotein C1 (apo-C1) ELISA Kit for Human

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: CD95 death-inducing signaling complex; cell body; cytoplasm; cytosol; membrane raft; neuron projection; nucleus; plasma membrane

Molecular Function: caspase binding; death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; receptor serine/threonine kinase binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptosis; behavioral response to cocaine; cell surface receptor signaling pathway; death-inducing signaling complex assembly; defense response to virus; induction of apoptosis via death domain receptors; innate immune response; lymph node development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of extrinsic apoptotic signaling pathway via death domain receptors; response to morphine; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development; toll-like receptor 3 signaling pathway; TRAIL-activated apoptotic signaling pathway; viral process

Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations