Probable ATP-Dependent RNA Helicase DDX41 (DDX41) ELISA Kit for Human

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]

DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.

Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: catalytic step 2 spliceosome; cytoplasm; cytosol; endoplasmic reticulum; membrane; nucleolus; nucleus; spliceosomal complex

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; DNA binding; metal ion binding; protein binding; RNA binding

Biological Process: apoptosis; cell differentiation; cell proliferation; defense response to virus; mRNA splicing, via spliceosome; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; regulation of type I interferon production; RNA secondary structure unwinding

Disease: Myeloproliferative/lymphoproliferative Neoplasms, Familial (multiple Types), Susceptibility To