Achaete-Scute Homolog 1 (ASCL1) ELISA Kit for Mouse

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 10|10 C1

Cellular Component: cell soma; nucleus; RNA polymerase II transcription factor complex

Molecular Function: bHLH transcription factor binding; chromatin binding; DNA binding; DNA binding transcription factor activity; double-stranded DNA binding; protein binding; protein dimerization activity; protein homodimerization activity; sequence-specific DNA binding

Biological Process: cell differentiation; cell maturation; central nervous system neuron development; cerebral cortex development; commitment of a neuronal cell to a specific type of neuron in the forebrain; enteric nervous system development; forebrain neuron differentiation; generation of neurons; glial cell differentiation; multicellular organism development; musculoskeletal movement, spinal reflex action; negative regulation of apoptosis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; neuroblast fate determination; neuroblast proliferation; neurogenesis; neuron development; neuron differentiation; neuron fate commitment; neuron fate specification; neuron migration; noradrenergic neuron development; noradrenergic neuron fate commitment; Notch signaling pathway; olfactory pit development; oligodendrocyte cell fate commitment; oligodendrocyte development; oligodendrocyte differentiation; parasympathetic nervous system development; pattern specification process; positive regulation of cell cycle; positive regulation of neural precursor cell proliferation; positive regulation of neurogenesis; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of epithelial cell differentiation; regulation of gene expression; regulation of mitotic cell cycle; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of timing of subpallium neuron differentiation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; spinal cord association neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; subpallium neuron fate commitment; sympathetic nervous system development; transcription, DNA-dependent; vestibular nucleus development