Estrogen Receptor Beta (ESR2) ELISA Kit for Rat

ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: cell soma; cilium; cytoplasm; mitochondrion; neuron projection; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: DNA binding; DNA binding transcription factor activity; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; hormone binding; peroxisome proliferator activated receptor binding; protein binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding

Biological Process: amygdala development; behavioral fear response; brain development; cerebellum development; female gonad development; hormone-mediated apoptotic signaling pathway; hypothalamus development; intracellular estrogen receptor signaling pathway; learning and/or memory; male gonad development; negative regulation of behavior; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; prostate gland development; regulation of cell proliferation; regulation of neuron apoptosis; regulation of transcription, DNA-templated; response to activity; response to drug; response to estradiol; response to estrogen; response to ethanol; response to genistein; response to hormone; response to insecticide; response to nutrient levels; response to organic cyclic compound; response to testosterone stimulus; response to water deprivation; Sertoli cell development; Sertoli cell proliferation; steroid hormone mediated signaling; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; uterus development; vagina development