Estradiol (ER) ELISA Kit for Rat

ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q11

Cellular Component: cytoplasm; Golgi apparatus; mitochondrion; neuron projection; nuclear chromatin; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; protein complex; T-tubule; terminal bouton

Molecular Function: ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA binding transcription factor activity; enzyme binding; estrogen receptor activity; estrogen receptor binding; estrogen response element binding; hormone binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein complex binding; protein kinase binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; TATA-binding protein binding; transcription factor binding; type 1 metabotropic glutamate receptor binding; zinc ion binding

Biological Process: androgen metabolic process; antral ovarian follicle growth; decidualization; elevation of cytosolic calcium ion concentration; epithelial cell development; intracellular estrogen receptor signaling pathway; male gonad development; negative regulation of glucose import; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transcriptional preinitiation complex assembly; regulation of apoptosis; regulation of inflammatory response; regulation of neuron apoptosis; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-templated; response to estradiol; response to estrogen; Sertoli cell development; Sertoli cell proliferation; stem cell differentiation; steroid hormone mediated signaling; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; uterus development; vagina development