Adenosine Receptor A2a (ADORA2A) ELISA Kit for Rat

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 20p12

Cellular Component: asymmetric synapse; axolemma; axon; cell soma; dendrite; endomembrane system; Golgi membrane; integral component of plasma membrane; intermediate filament; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane

Molecular Function: alpha-actinin binding; enzyme binding; G-protein coupled adenosine receptor activity; identical protein binding; protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding

Biological Process: adenosine receptor signaling pathway; adenylate cyclase activation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; astrocyte activation; eating behavior; excitatory postsynaptic potential; G-protein coupled receptor signaling pathway; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of cAMP biosynthetic process; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of protein secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic plasticity; regulation of transcription, DNA-templated; response to alkaloid; response to amphetamine; response to caffeine; response to drug; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation