Estradiol 17 Beta-Dehydrogenase 5 (AKR1C6) ELISA Kit for Mouse

AKR1C4: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Belongs to the aldo/keto reductase family.

Protein type: Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - C21-steroid hormone; EC 1.1.1.225; EC 1.1.1.357; Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis

Cellular Component: cytoplasm; nucleus

Molecular Function: (R)-2-hydroxyglutarate dehydrogenase activity; (R)-2-hydroxyisocaproate dehydrogenase activity; 2-hydroxytetrahydrofuran dehydrogenase activity; 20-alpha-hydroxysteroid dehydrogenase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; 3-ketoglucose-reductase activity; 5-exo-hydroxycamphor dehydrogenase activity; acetoin dehydrogenase activity; aldo-keto reductase activity; arabinose reductase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; D-arabinitol dehydrogenase (NADP+) activity; epoxide dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; gluconate dehydrogenase activity; isocitrate dehydrogenase activity; mevaldate reductase activity; oxidoreductase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenylcoumaran benzylic ether reductase activity; retinal dehydrogenase activity; steroid dehydrogenase activity; steroid dehydrogenase activity, acting on the CH-CH group of donors; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; testosterone 17-beta-dehydrogenase (NADP+) activity; xylose reductase activity

Biological Process: lipid metabolic process; negative regulation of nuclear mRNA splicing, via spliceosome; response to drug; response to estrogen stimulus; steroid biosynthetic process; steroid metabolic process