Alpha-1a Adrenergic Receptor (ADRA1A) ELISA Kit for Mouse

This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cytosol; integral to membrane; integral to plasma membrane; membrane; nuclear membrane; nucleus; plasma membrane; T-tubule; Z disc

Molecular Function: adrenoceptor activity; alpha1-adrenergic receptor activity; G-protein coupled receptor activity; protein heterodimerization activity; signal transducer activity

Biological Process: adult heart development; aging; cell growth; cell-cell signaling; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); micturition; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; negative regulation of Rho protein signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; organ growth; phospholipase C activation; positive regulation of action potential; positive regulation of heart rate; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of MAPKKK cascade; positive regulation of smooth muscle contraction; positive regulation of synaptic transmission, GABAergic; positive regulation of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of vasoconstriction; regulation of muscle contraction; regulation of vasoconstriction; response to drug; response to hormone stimulus; signal transduction