Disintegrin and Metalloproteinase Domain-Containing Protein 9 (ADAM9) ELISA Kit for Human

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: cell surface; cytoplasm; extracellular space; focal adhesion; integral to membrane

Molecular Function: collagen binding; integrin binding; laminin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein kinase C binding; SH3 domain binding; zinc ion binding

Biological Process: activation of MAPKK activity; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion mediated by integrin; cell-matrix adhesion; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; keratinocyte differentiation; membrane protein ectodomain proteolysis; monocyte activation; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell adhesion mediated by integrin; positive regulation of keratinocyte migration; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein secretion; response to calcium ion; response to glucocorticoid stimulus; response to hydrogen peroxide; response to manganese ion; transforming growth factor beta receptor signaling pathway

Disease: Cone-rod Dystrophy 9