C Reactive Protein (CRP) Antibody – Mouse Monoclonal

Monoclonal antibody to C reactive protein (CRP)

C-reactive protein (CRP) is a ring-shaped, protein and a member of the pentraxin protein family. It is synthesized in the liver in response to factors released by macrophages and fat cells (adipocytes). The gene for CRP is located on the first chromosome (1q21-q23).
Levels of plasma CRP rise in response to inflammation (e.g. following interleukin-6 secretion from macrophages and T cells). CRP binds to lysophosphatidylcholine that is expressed on the surface of dead or dying cells in order to activate the complement system via the C1Q complex. This response is referred to as the acute phase response initiated by a rise in the concentration of IL-6, originating from macrophages and/ or adipocytes. This acute phase response occurs in reaction to a wide range of acute and chronic inflammatory conditions such as bacterial, viral, or fungal infections; rheumatic and other inflammatory diseases; malignancy; and tissue injury and necrosis. These conditions cause release of interleukin-6 and other cytokines that trigger the synthesis of CRP and fibrinogen by the liver.

The concentration of human reactive protein in the test sample can be derived from a standard curve. The details of reagents in this kit can be found in the product datasheet
These antibodies have specificity to human CRP. Applicationsof this protein antibody include both western blotting, IHC, antibody arrays and ELISA kit development for research purposes such target identification.

Small volumes of anti-CRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.