Rabbit Anti-CX3CR1 Polyclonal Antibody – Cat# MBS315862

N-Terminal V28 (CX3CR1) Antibody – Rabbit Polyclonal

Name: CX3CR1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS315862
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS315862

MBS315862 is an antibody targeting CX3CR1. Also known as Rabbit anti CX3CR1 N-term. V28. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CX3CR1, N-terminal V28, Polyclonal Antibody

Full Product Name

Rabbit anti CX3CR1 N-term. V28

Product Gene Name

anti-CX3CR1 antibody

Product Synonym Names

Rabbit Antibody to CX3CR1, N-terminal V28

Clonality

Polyclonal

Host

Rabbit

Form/Format

Affinity Purified, Liquid

Purity/Purification

Immunoaffinity chromatography

Concentration

1mg/ml (lot specific)

Specificity

CX3CR1, N-terminal V28
Reacts with CX3CR1 in human, mouse and rat samples. CX3CR1 was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration

Preparation and Storage

Store (up to 1 year) at 2 to 8 degree C.

Molecular Weight

40,396 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (39304985..39323226, complement). Location: 3p21; 3p21.3

OMIM

601470

3D Structure

ModBase 3D Structure for P49238

Immunogen

Peptide corresponding to amino acids 2-21 of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3, 4)

Buffer

PBS

Preservative

0.02% Sodium azide

Important Note

Centrifuge before opening to ensure complete recovery of vial contents.

Warnings

This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Product Categories/Family for anti-CX3CR1 antibody

Polyclonal Antibodies to Cytokines and Growth Factors

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CX3CR1 antibody

Flow Cytometry, Western Blot

Product References and Citations for anti-CX3CR1 antibody

• Raport C.J., et al., (1995), "The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues", Gene, 163, 295-299.
• Combadiere C., et al

Other Notes

Small volumes of anti-CX3CR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CX3CR1. It may not necessarily be applicable to this product.

NCBI GI #

1351394

NCBI GeneID

1524

NCBI Accession #

P49238.1

UniProt Primary Accession #

P49238

UniProt Secondary Accession #

A0N0N6; B2R5Z4

UniProt Related Accession #

P49238

NCBI Official Full Name

CX3C chemokine receptor 1

NCBI Official Synonym Full Names

chemokine (C-X3-C motif) receptor 1

NCBI Official Symbol

CX3CR1

NCBI Official Synonym Symbols

V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1

UniProt Protein Name

CX3C chemokine receptor 1

UniProt Synonym Protein Names

Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

Protein Family

CX3C chemokine receptor

UniProt Gene Name

CX3CR1

UniProt Synonym Gene Names

CMKBRL1; GPR13

UniProt Entry Name

CX3C1_HUMAN

NCBI Protein Information

CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; OTTHUMP00000209587; OTTHUMP00000209588; OTTHUMP00000209589; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1

NCBI Summary for CX3CR1

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

UniProt Comments for CX3CR1

Function: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.

Subunit structure: Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160. Ref.9

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in lymphoid and neural tissues.

Polymorphism: Variations in CX3CR1 are associated with rapid progression to AIDS [

MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Research Articles on CX3CR1

1. CX3CL1-CX3CR1 is a novel inflammatory adipose chemokine system that modulates monocyte adhesion to adipocytes and is associated with obesity, insulin resistance, and type 2 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CX3CR1 antibody

Reference Product	PubMed Publications
CX3CL1 antibody	>281 publications with CX3CR1 and CX3CL1

Pathways associated with anti-CX3CR1 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-CX3CR1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>169 publications with CX3CR1 and Inflammation
Immune System Diseases Antibodies	>109 publications with CX3CR1 and Immune System Diseases
Neoplasms Antibodies	>54 publications with CX3CR1 and Neoplasms
Arteriosclerosis Antibodies	>50 publications with CX3CR1 and Arteriosclerosis
Pain Antibodies	>33 publications with CX3CR1 and Pain
Macular Degeneration Antibodies	>32 publications with CX3CR1 and Macular Degeneration
Coronary Disease Antibodies	>31 publications with CX3CR1 and Coronary Disease
Liver Diseases Antibodies	>13 publications with CX3CR1 and Liver Diseases
Neuroectodermal Tumors Antibodies	>12 publications with CX3CR1 and Neuroectodermal Tumors
Diabetes Mellitus Antibodies	>11 publications with CX3CR1 and Diabetes Mellitus

Organs/Tissues associated with anti-CX3CR1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>276 publications with CX3CR1 and Blood
Brain Antibodies	>89 publications with CX3CR1 and Brain
Kidney Antibodies	>41 publications with CX3CR1 and Kidney
Lung Antibodies	>40 publications with CX3CR1 and Lung
Spinal Cord Antibodies	>33 publications with CX3CR1 and Spinal Cord
Liver Antibodies	>20 publications with CX3CR1 and Liver
Spleen Antibodies	>10 publications with CX3CR1 and Spleen
Thymus Antibodies	>7 publications with CX3CR1 and Thymus
Pancreas Antibodies	>6 publications with CX3CR1 and Pancreas
Connective Tissue Antibodies	>6 publications with CX3CR1 and Connective Tissue