Apolipoprotein (a) (Apo (a)) (APOA2) Antibody – Sheep Polyclonal

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq]

Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Subunit structure: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP. Ref.14 Ref.15 Ref.18

Subcellular location: Secreted.

Tissue specificity: Plasma; synthesized in the liver and intestine.

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Sequence similarities: Belongs to the apolipoprotein A2 family.

Mass spectrometry: Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Ref.16Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II. Ref.16Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer. Ref.16Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with apolipoprotein A-II(1-76). Ref.16Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Ref.16Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer. Ref.16