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NFYC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3204419

This is a rabbit polyclonal antibody against NFYC. It was validated on Western Blot and immunohistochemistryTarget Description: NFYC is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
NFYC, Polyclonal Antibody
Full Product Name
NFYC antibody - C-terminal region
Product Gene Name
anti-NFYC antibody
Product Synonym Gene Name
CBF-C; CBFC; DKFZp667G242; FLJ45775; H1TF2A; HAP5; HSM; NF-YC
Immunogen Sequence
Synthetic peptide located within the following region: GTQVVQGQIQ TLATNAQQIT QTEVQQGQQQ FSQFTDGQQL YQIQQVTMPA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NFYC peptide (MBS3229386) is used for blocking the activity of NFYC antibody (MBS3204419)
Molecular Weight
37kDa
OMIM
605344
3D Structure
ModBase 3D Structure for Q13952
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human NFYC

Product Categories/Family for anti-NFYC antibody

Polyclonal; Signal Proteins; Lymphocyte Signaling; Membrane Protein; Transcription Regulation; Developmental Biology; Immunohistochemistry; Receptors; Transcription Factors
Applications Tested/Suitable for anti-NFYC antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-NFYC antibody

Human Liver
Rabbit Anti-NFYC Polyclonal Antibody – Cat# MBS3204419

Western Blot (WB) of anti-NFYC antibody

Host: Mouse
Target Name: NFYC
Sample Tissue: Mouse Brain
Antibody Dilution: 1ug/ml
Rabbit Anti-NFYC Polyclonal Antibody, Western Blot (WB) – Cat# MBS3204419

Western Blot (WB) of anti-NFYC antibody

WB Suggested Anti-NFYC Antibody Titration: 0.25 ug/ml
Positive Control: 293T cells lysateThere is BioGPS gene expression data showing that NFYC is expressed in HEK293T
Rabbit Anti-NFYC Polyclonal Antibody, Western Blot (WB) – Cat# MBS3204419

Other Notes

Small volumes of anti-NFYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NFYC purchase

MBS3204419 is an antibody targeting NFYC. Also known as NFYC antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NFYC. It may not necessarily be applicable to this product.

NCBI GI #
217272829
NCBI GeneID
4802
NCBI Accession #
NP_055038
UniProt Primary Accession #
Q13952
UniProt Related Accession #
Q13952
GenBank Nucleotide #
NM_014223
NCBI Official Full Name
nuclear transcription factor Y subunit gamma isoform 3
NCBI Official Synonym Full Names
nuclear transcription factor Y subunit gamma
NCBI Official Symbol
NFYC
NCBI Official Synonym Symbols
HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
UniProt Protein Name
Nuclear transcription factor Y subunit gamma
UniProt Synonym Protein Names
CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2
Protein Family
Nuclear transcription factor
UniProt Gene Name
NFYC
UniProt Synonym Gene Names
NF-YC
UniProt Entry Name
NFYC_HUMAN
NCBI Protein Information
nuclear transcription factor Y subunit gamma

NCBI Summary for NFYC

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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UniProt Comments for NFYC

NFYC: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Belongs to the NFYC/HAP5 subunit family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; CCAAT-binding factor complex; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: regulation of transcription from RNA polymerase II promoter; protein folding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cellular lipid metabolic process
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Research Articles on NFYC

1. NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NFYC antibody

 Reference Product  PubMed Publications
 NFYB antibody  >7 publications with NFYC and NFYB
 NFYA antibody  >6 publications with NFYC and NFYA
 MYC antibody  >2 publications with NFYC and MYC

Pathways associated with anti-NFYC antibody

 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By ATF6-alpha Pathway antibodies  Activation Of Chaperone Genes By ATF6-alpha Pathway Diagram
 Activation Of Chaperones By ATF6-alpha Pathway antibodies  Activation Of Chaperones By ATF6-alpha Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Activation Of Genes By ATF4 Pathway antibodies  Activation Of Genes By ATF4 Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-NFYC antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with NFYC and Kidney Diseases

Organs/Tissues associated with anti-NFYC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with NFYC and Blood
 Kidney Antibodies  >2 publications with NFYC and Kidney
 Lung Antibodies  >2 publications with NFYC and Lung
 Lymph Antibodies  >1 publications with NFYC and Lymph
 Lymph Node Antibodies  >1 publications with NFYC and Lymph Node
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