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TMEM16C (ANO3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3209743

This is a rabbit polyclonal antibody against TMEM16C. It was validated on Western Blot using a cell lysate as a positive control.Target Description: TMEM16C is a multi-pass membrane proteinPotential. It belongs to the anoctamin family. TMEM16C may act as a… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
TMEM16C (ANO3), Polyclonal Antibody
Full Product Name
TMEM16C antibody - C-terminal region
Product Gene Name
Product Synonym Gene Name
C11orf25; GENX-3947; TMEM16C
Immunogen Sequence
AFVIAITSDY IPRFVYEYKY GPCANHVEPS ENCLKGYVNN SLSFFDLSEL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Tested Reactivity: Human
Predicted Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Concentration
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml (lot specific)
Preparation and Storage
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TMEM16C peptide (MBS3234699) is used for blocking the activity of TMEM16C antibody (MBS3209743)
Molecular Weight
115kDa
3D Structure
ModBase 3D Structure for Q9BYT9
Protein Size (# AA)
981 amino acids
Blocking Peptide
For anti-ANO3 (MBS3209743) antibody is MBS3234699
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human TMEM16C
Replacement Item
This antibody may replace item sc-244370 from Santa Cruz Biotechnology.
Predicted Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Product Categories/Family for anti-ANO3 antibody

Applications Tested/Suitable for anti-ANO3 antibody
Western Blot (WB)

Western Blot (WB) of anti-ANO3 antibody

WB Suggested Anti-TMEM16C Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate
Rabbit Anti-ANO3 Polyclonal Antibody – Cat# MBS3209743

Other Notes

Small volumes of anti-ANO3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANO3 purchase

MBS3209743 is an antibody targeting ANO3. Also known as TMEM16C antibody - C-terminal region. Reactive in Tested Reactivity: Human
Predicted Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANO3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
anoctamin-3 isoform 2
NCBI Official Synonym Full Names
anoctamin 3
NCBI Official Symbol
ANO3
NCBI Official Synonym Symbols
DYT23; DYT24; TMEM16C; C11orf25; GENX-3947
UniProt Protein Name
Anoctamin-3
UniProt Synonym Protein Names
Transmembrane protein 16C
Protein Family
UniProt Gene Name
ANO3
UniProt Synonym Gene Names
C11orf25; TMEM16C
NCBI Protein Information
anoctamin-3

NCBI Summary for ANO3

The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
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UniProt Comments for ANO3

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (). Does not exhibit calcium-activated chloride channel (CaCC) activity.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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