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MAS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3210242

This is a rabbit polyclonal antibody against MAS1. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MAS1, Polyclonal Antibody
Full Product Name
MAS1 antibody - middle region
Product Gene Name
Product Synonym Gene Name
MAS; MGC119966
Immunogen Sequence
Synthetic peptide located within the following region: VIIFIAILSF LVFTPLMLVS STILVVKIRK NTWASHSSKL YIVIMVTIII
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
MAS1 peptide (MBS3235198) is used for blocking the activity of MAS1 antibody (MBS3210242)
Molecular Weight
37kDa
OMIM
165180
3D Structure
ModBase 3D Structure for P04201
Homology
Cow: 93%; Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MAS1
Applications Tested/Suitable for anti-MAS1 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-MAS1 antibody

Immunohistochemistry with Human Heart lysate tissue at an antibody concentration of 5.0ug/ml using anti-MAS1 antibody
Rabbit Anti-MAS1 Polyclonal Antibody – Cat# MBS3210242

Western Blot (WB) of anti-MAS1 antibody

WB Suggested Anti-MAS1 Antibody Titration: 0.25ug/ml
Positive Control: HepG2 cell lysate
Rabbit Anti-MAS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3210242

Other Notes

Small volumes of anti-MAS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAS1 purchase

MBS3210242 is an antibody targeting MAS1. Also known as MAS1 antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAS1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
proto-oncogene Mas
NCBI Official Synonym Full Names
MAS1 proto-oncogene, G protein-coupled receptor
NCBI Official Symbol
MAS1
NCBI Official Synonym Symbols
MAS; MGRA
UniProt Protein Name
Proto-oncogene Mas
UniProt Gene Name
MAS1
UniProt Synonym Gene Names
MAS
UniProt Entry Name
MAS_HUMAN
NCBI Protein Information
proto-oncogene Mas

NCBI Summary for MAS1

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
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UniProt Comments for MAS1

MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family.

Protein type: Oncoprotein; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q25.3-q26

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; angiotensin type II receptor activity; peptide hormone binding; peptide binding; angiotensin receptor activity

Biological Process: response to drug; anatomical structure morphogenesis; male gonad development; hippocampus development; activation of NF-kappaB-inducing kinase; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of protein amino acid phosphorylation; regulation of inflammatory response; positive regulation of cell proliferation; spermatogenesis; response to activity; positive regulation of DNA replication
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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