• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

STAMBP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3211350

This is a rabbit polyclonal antibody against STAMBP. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules.… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAMBP, Polyclonal Antibody
Full Product Name
STAMBP antibody - N-terminal region
Product Gene Name
anti-STAMBP antibody
Product Synonym Gene Name
AMSH; MGC126516; MGC126518
Immunogen Sequence
Synthetic peptide located within the following region: SDHGDVSLPP EDRVRALSQL GSAVEVNEDI PPRRYFRSGV EIIRMASIYS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
STAMBP peptide (MBS3236301) is used for blocking the activity of STAMBP antibody (MBS3211350)
Molecular Weight
48kDa
OMIM
U73522 mRNA
3D Structure
ModBase 3D Structure for O95630
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human STAMBP

Product Categories/Family for anti-STAMBP antibody

Polyclonal; Lymphocyte Signaling; Meiosis/Mitosis/Cell Cycle
Applications Tested/Suitable for anti-STAMBP antibody
Western Blot (WB)

Western Blot (WB) of anti-STAMBP antibody

WB Suggested Anti-STAMBP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysateSTAMBP is supported by BioGPS gene expression data to be expressed in Jurkat
Rabbit Anti-STAMBP Polyclonal Antibody – Cat# MBS3211350

Other Notes

Small volumes of anti-STAMBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAMBP purchase

MBS3211350 is an antibody targeting STAMBP. Also known as STAMBP antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAMBP. It may not necessarily be applicable to this product.

NCBI GI #
47132534
NCBI GeneID
10617
NCBI Accession #
NP_998787
UniProt Primary Accession #
O95630
UniProt Related Accession #
O95630
GenBank Nucleotide #
NM_213622
NCBI Official Full Name
STAM-binding protein isoform 1
NCBI Official Synonym Full Names
STAM binding protein
NCBI Official Symbol
STAMBP
NCBI Official Synonym Symbols
AMSH; MICCAP
UniProt Protein Name
STAM-binding protein
UniProt Synonym Protein Names
Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Protein Family
STAM-binding protein
UniProt Gene Name
STAMBP
UniProt Synonym Gene Names
AMSH
NCBI Protein Information
STAM-binding protein

NCBI Summary for STAMBP

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for STAMBP

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Show more

Research Articles on STAMBP

1. Contrary to previously reported STAMBP mutations, the Ser236Phe mutation did not lead to constitutive activation of the PI3K-AKT-mTOR pathway in patient-derived LCLs, as indicated by the expression of phosphorylated S6 ribosomal protein, suggesting that it is not the major pathomechanism underlying the disorder in this patient.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAMBP antibody

 Reference Product  PubMed Publications
 STAM antibody  >21 publications with STAMBP and STAM
 EGFR antibody  >5 publications with STAMBP and EGFR
 CHMP1A antibody  >3 publications with STAMBP and CHMP1A
 GRB2 antibody  >2 publications with STAMBP and GRB2
 VPS24 antibody  >2 publications with STAMBP and VPS24
 SMURF2 antibody  >1 publications with STAMBP and SMURF2
 RNF11 antibody  >1 publications with STAMBP and RNF11
 STAM2 antibody  >1 publications with STAMBP and STAM2

Pathways associated with anti-STAMBP antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram

Diseases associated with anti-STAMBP antibody

 Disease Name  Pubmed Publications
 Microcephaly Antibodies  >4 publications with STAMBP and Microcephaly
 Epilepsy Antibodies  >3 publications with STAMBP and Epilepsy
 Brain Diseases Antibodies  >2 publications with STAMBP and Brain Diseases
 Weight Gain Antibodies  >1 publications with STAMBP and Weight Gain
 Developmental Disabilities Antibodies  >1 publications with STAMBP and Developmental Disabilities

Organs/Tissues associated with anti-STAMBP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with STAMBP and Brain
 Skin Antibodies  >2 publications with STAMBP and Skin
 Parathyroid Antibodies  >1 publications with STAMBP and Parathyroid
 Vascular Antibodies  >1 publications with STAMBP and Vascular
 Testis Antibodies  >1 publications with STAMBP and Testis
 Embryonic Tissue Antibodies  >1 publications with STAMBP and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000