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NRDC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3214037

This is a rabbit polyclonal antibody against NRD1. It was validated on Western Blot using a cell lysate as a positive control.Target Description: This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NRDC, Polyclonal Antibody
Full Product Name
NRDC Antibody - middle region
Product Gene Name
Product Synonym Gene Name
NRD1; hNRD1; hNRD2
Immunogen Sequence
Synthetic peptide located within the following region: GSKMLSVHVV GYGKYELEED GTPSSEDSNS SCEVMQLTYL PTSPLLADCI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Tested Reactivity: Human
Predicted Reactivity: Cow, Horse, Human, Pig
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Concentration
Batch dependent within range: 100ul at 0.5- 1mg/ml (lot specific)
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NRDC peptide (MBS3238975) is used for blocking the activity of NRDC antibody (MBS3214037)
Molecular Weight
132kDa
OMIM
602651
3D Structure
ModBase 3D Structure for O43847
Homology
Cow: 93%; Horse: 86%; Human: 100%; Pig: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human NRD1
Protein Size
1151 amino acids
Protein Interactions
FBXW11; UBC; rev; SETSIP; PUS1; P3H1; ELAC2; XPO5; NSUN2; PDIA6; YARS; DNAJC7; TSN; PPP3CA; PPP2R2A; PPP2CA; PFDN5; PFDN1; PPP1R12A; MSH2; PNKP; HSPB1; MOB2; MOB1A; STK3; NRD1; HIST2H3C; UACA; COBLL1; NCOR2; NCOR1; HDAC3; IQGAP1; MAD1L1; TBL1X; UIMC1; BTR

Product Categories/Family for anti-NRDC antibody

Applications Tested/Suitable for anti-NRDC antibody
Western Blot (WB)

Western Blot (WB) of anti-NRDC antibody

WB Suggested Anti-NRD1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate
Rabbit Anti-NRDC Polyclonal Antibody – Cat# MBS3214037

Other Notes

Small volumes of anti-NRDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRDC purchase

MBS3214037 is an antibody targeting NRDC. Also known as NRDC Antibody - middle region. Reactive in Tested Reactivity: Human
Predicted Reactivity: Cow, Horse, Human, Pig. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRDC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
nardilysin isoform b
NCBI Official Synonym Full Names
nardilysin convertase
NCBI Official Symbol
NRDC
NCBI Official Synonym Symbols
NRD1; hNRD1; hNRD2
UniProt Protein Name
Nardilysin
UniProt Synonym Protein Names
N-arginine dibasic convertase
Protein Family
UniProt Gene Name
NRD1
UniProt Synonym Gene Names
NRD convertase; NRD-C
UniProt Entry Name
NRDC_HUMAN
NCBI Protein Information
nardilysin

NCBI Summary for NRDC

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
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UniProt Comments for NRDC

Function: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Catalytic activity: Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.

Sequence similarities: Belongs to the peptidase M16 family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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