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GNL3L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3214056

This is a rabbit polyclonal antibody against GNL3L. It was validated on Western Blot using a cell lysate as a positive control.Target Description: GNL3L is required for normal processing of ribosomal pre-rRNA and cell proliferation. More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNL3L, Polyclonal Antibody
Full Product Name
GNL3L antibody - N-terminal region
Product Gene Name
anti-GNL3L antibody
Product Synonym Gene Name
FLJ10613; RP11-353K22.1
Immunogen Sequence
Synthetic peptide located within the following region: MMKLRHKNKK PGEGSKGHKK ISWPYPQPAK QNGKKATSKV PSAPHFVHPN
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Human, Mouse, Pig, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GNL3L peptide (MBS3238994) is used for blocking the activity of GNL3L antibody (MBS3214056)
Molecular Weight
65kDa
OMIM
300873
3D Structure
ModBase 3D Structure for Q9NVN8
Homology
Cow: 86%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 86%; Rat: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GNL3L

Product Categories/Family for anti-GNL3L antibody

Polyclonal; Various
Applications Tested/Suitable for anti-GNL3L antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-GNL3L antibody

Rabbit Anti-GNL3L Antibody
Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver
Observed Staining: Nuclear in hepatocytes, moderate signal, low tissue distribution
Primary Antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Protocol located in Reviews and Data.
Rabbit Anti-GNL3L Polyclonal Antibody – Cat# MBS3214056

Western Blot (WB) of anti-GNL3L antibody

WB Suggested Anti-GNL3L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Lung
Rabbit Anti-GNL3L Polyclonal Antibody, Western Blot (WB) – Cat# MBS3214056

Other Notes

Small volumes of anti-GNL3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNL3L purchase

MBS3214056 is an antibody targeting GNL3L. Also known as GNL3L antibody - N-terminal region. Reactive in Cow, Dog, Human, Mouse, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GNL3L. It may not necessarily be applicable to this product.

NCBI GI #
9506611
NCBI GeneID
54552
NCBI Accession #
NP_061940
UniProt Primary Accession #
Q9NVN8
UniProt Related Accession #
Q9NVN8
GenBank Nucleotide #
NM_019067
NCBI Official Full Name
guanine nucleotide-binding protein-like 3-like protein
NCBI Official Synonym Full Names
G protein nucleolar 3 like
NCBI Official Symbol
GNL3L
NCBI Official Synonym Symbols
GNL3B
UniProt Protein Name
Guanine nucleotide-binding protein-like 3-like protein
Protein Family
Guanine nucleotide-binding protein-like 3-like protein
UniProt Gene Name
GNL3L
UniProt Entry Name
GNL3L_HUMAN
NCBI Protein Information
guanine nucleotide-binding protein-like 3-like protein

NCBI Summary for GNL3L

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

UniProt Comments for GNL3L

GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: metabolic process; ribosome biogenesis and assembly
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Research Articles on GNL3L

1. GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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