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TBX5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9412700

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TBX5, Polyclonal Antibody
Full Product Name
TBX5 Antibody
Product Gene Name
anti-TBX5 antibody
Product Synonym Names
HOS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
2.3 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total TBX5 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
SDS-PAGE: 58kd
OMIM
142900
3D Structure
ModBase 3D Structure for Q99593
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human T-box 5
Target Name
TBX5

Product Categories/Family for anti-TBX5 antibody

Total protein Ab
Applications Tested/Suitable for anti-TBX5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TBX5 antibody
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200

Testing Data of anti-TBX5 antibody

Gel: 8%SDS-PAGE Lysates (from left to right): Mouse kidney tissue Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes
Rabbit Anti-TBX5 Polyclonal Antibody – Cat# MBS9412700

Immunohistochemistry (IHC) of anti-TBX5 antibody

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/35.
Rabbit Anti-TBX5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9412700

Other Notes

Small volumes of anti-TBX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBX5 purchase

MBS9412700 is an antibody targeting TBX5. Also known as TBX5 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBX5. It may not necessarily be applicable to this product.

NCBI GI #
18201892
NCBI GeneID
6910
NCBI Accession #
NP_000183
UniProt Primary Accession #
Q99593
UniProt Secondary Accession #
O15301; Q96TB0; Q9Y4I2; A6ND77
UniProt Related Accession #
Q99593
GenBank Nucleotide #
NM_000192.3
NCBI Official Full Name
T-box transcription factor TBX5 isoform 1
NCBI Official Synonym Full Names
T-box 5
NCBI Official Symbol
TBX5
NCBI Official Synonym Symbols
HOS
UniProt Protein Name
T-box transcription factor TBX5
Protein Family
T-box transcription factor
UniProt Gene Name
TBX5
UniProt Synonym Gene Names
T-box protein 5
UniProt Entry Name
TBX5_HUMAN
NCBI Protein Information
T-box transcription factor TBX5

UniProt Comments for TBX5

TBX5: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX5 are the cause of Holt-Oram syndrome (HOS). HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity

Biological Process: embryonic forelimb morphogenesis; pericardium development; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; heart development; pattern specification process; cardiac muscle cell differentiation; forelimb morphogenesis; negative regulation of cell proliferation; apoptotic nuclear changes; cell-cell signaling; negative regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; morphogenesis of an epithelium; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation; lung development; embryonic limb morphogenesis

Disease: Holt-oram Syndrome
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Research Articles on TBX5

1. TBX5 mutation is involved in the development of cardiac conduction disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBX5 antibody

 Reference Product  PubMed Publications
 NKX2-5 antibody  >130 publications with TBX5 and NKX2-5
 GATA4 antibody  >124 publications with TBX5 and GATA4
 FGF10 antibody  >24 publications with TBX5 and FGF10
 NPPA antibody  >17 publications with TBX5 and NPPA
 SALL4 antibody  >15 publications with TBX5 and SALL4
 SMARCD3 antibody  >6 publications with TBX5 and SMARCD3
 GJA5 antibody  >2 publications with TBX5 and GJA5
 MEF2A antibody  >1 publications with TBX5 and MEF2A
 WWTR1 antibody  >1 publications with TBX5 and WWTR1

Pathways associated with anti-TBX5 antibody

 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway antibodies  YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway Diagram

Diseases associated with anti-TBX5 antibody

 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >151 publications with TBX5 and Heart Defects, Congenital
 Holt-Oram syndrome Antibodies  >117 publications with TBX5 and Holt-Oram syndrome
 Disease Models, Animal Antibodies  >10 publications with TBX5 and Disease Models, Animal
 Hypertrophy Antibodies  >10 publications with TBX5 and Hypertrophy
 Eye Abnormalities Antibodies  >9 publications with TBX5 and Eye Abnormalities
 Abnormalities, Drug-Induced Antibodies  >8 publications with TBX5 and Abnormalities, Drug-Induced
 Fibrosis Antibodies  >4 publications with TBX5 and Fibrosis
 Cardiomegaly Antibodies  >4 publications with TBX5 and Cardiomegaly
 Respiratory Tract Diseases Antibodies  >3 publications with TBX5 and Respiratory Tract Diseases
 Edema Antibodies  >3 publications with TBX5 and Edema

Organs/Tissues associated with anti-TBX5 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >351 publications with TBX5 and Heart
 Embryonic Tissue Antibodies  >134 publications with TBX5 and Embryonic Tissue
 Lung Antibodies  >17 publications with TBX5 and Lung
 Liver Antibodies  >4 publications with TBX5 and Liver
 Trachea Antibodies  >4 publications with TBX5 and Trachea
 Uncharacterized Tissue Antibodies  >1 publications with TBX5 and Uncharacterized Tissue
 Prostate Antibodies  >1 publications with TBX5 and Prostate
 Esophagus Antibodies  >1 publications with TBX5 and Esophagus
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