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CANX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3214490

This is a rabbit polyclonal antibody against CANX. It was validated on Western BlotTarget Description: This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated… More details

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Product Overview

Online Datasheet in PDF
Product Name
CANX, Polyclonal Antibody
Full Product Name
CANX antibody - C-terminal region
Product Gene Name
anti-CANX antibody
Product Synonym Gene Name
CNX; FLJ26570; IP90; P90
Immunogen Sequence
Synthetic peptide located within the following region: RPWLWVVYIL TVALPVFLVI LFCCSGKKQT SGMEYKKTDA PQPDVKEEEE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CANX peptide (MBS3239427) is used for blocking the activity of CANX antibody (MBS3214490)
Molecular Weight
65kDa
OMIM
114217
3D Structure
ModBase 3D Structure for P27824
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human CANX

Product Categories/Family for anti-CANX antibody

Polyclonal; Signaling Intermediate; Membrane Protein; Drugs and Drug Metabolism; Disease Related; Glycosylation
Applications Tested/Suitable for anti-CANX antibody
Western Blot (WB)

Western Blot (WB) of anti-CANX antibody

Researcher: DR. Kimilia Kent, Emory University
Application: Western blotting
Species + Tissue/Cell type: Rat Inner Medulla ~ 17.5 ug
How many ug's of tissue/cell lysate run on the gel:
1. 17.5 ug rat inner medulla lysate
2. 17.5 ug rat inner medulla lysate
3. 17.5 ug rat inner medulla lysate
4. 17.5 ug rat inner medulla lysate
5. 17.5 ug rat inner medulla lysate
6. 17.5 ug rat inner medulla lysate
Primary antibody dilution: 1:2000
Secondary antibody: Alexa 680 goat anti-rabbit
Secondary antibody dilution: 1:4000
Rabbit Anti-CANX Polyclonal Antibody – Cat# MBS3214490

Western Blot (WB) of anti-CANX antibody

WB Suggested Anti-CANX Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: A549 cell lysateCANX is strongly supported by BioGPS gene expression data to be expressed in Human A549 cells
Rabbit Anti-CANX Polyclonal Antibody, Western Blot (WB) – Cat# MBS3214490

Other Notes

Small volumes of anti-CANX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CANX purchase

MBS3214490 is an antibody targeting CANX. Also known as CANX antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CANX. It may not necessarily be applicable to this product.

NCBI GI #
10716563
NCBI GeneID
821
NCBI Accession #
NP_001737
UniProt Primary Accession #
P27824
GenBank Nucleotide #
NM_001746
NCBI Official Full Name
calnexin isoform d
UniProt Protein Name
Calnexin
UniProt Synonym Protein Names
IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
UniProt Gene Name
CANX
UniProt Entry Name
CALX_HUMAN

UniProt Comments for CANX

Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Protein type: Endoplasmic reticulum; Calcium-binding; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum lumen; dendritic spine; cell soma; membrane; axon; melanosome; ribosome

Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; carbohydrate binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CANX antibody

 Reference Product  PubMed Publications
 CALR antibody  >2 publications with CANX and CALR
 PDIA3 antibody  >1 publications with CANX and PDIA3

Pathways associated with anti-CANX antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Assembly Of Viral Components At The Budding Site Pathway antibodies  Assembly Of Viral Components At The Budding Site Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway antibodies  Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway Diagram
 Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway antibodies  Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway Diagram

Diseases associated with anti-CANX antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with CANX and Carcinoma
 Adenocarcinoma Antibodies  >2 publications with CANX and Adenocarcinoma
 Nervous System Diseases Antibodies  >1 publications with CANX and Nervous System Diseases
 Lung Diseases Antibodies  >1 publications with CANX and Lung Diseases
 Liver Diseases Antibodies  >1 publications with CANX and Liver Diseases
 Heart Diseases Antibodies  >1 publications with CANX and Heart Diseases

Organs/Tissues associated with anti-CANX antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with CANX and Lung
 Liver Antibodies  >2 publications with CANX and Liver
 Testis Antibodies  >2 publications with CANX and Testis
 Heart Antibodies  >1 publications with CANX and Heart
 Blood Antibodies  >1 publications with CANX and Blood
 Kidney Antibodies  >1 publications with CANX and Kidney
 Skin Antibodies  >1 publications with CANX and Skin
 Uterus Antibodies  >1 publications with CANX and Uterus
 Embryonic Tissue Antibodies  >1 publications with CANX and Embryonic Tissue
 Brain Antibodies  >1 publications with CANX and Brain
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