Rabbit Anti-MRGPRX2 Polyclonal Antibody – Cat# MBS3214566

WB Suggested Anti-MRGPRX2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Hela cell lysate

MRGPRX2 Antibody – Rabbit Polyclonal

Name: MRGPRX2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3214566
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3214566

This is a rabbit polyclonal antibody against MRGPRX2. It was validated on Western BlotTarget Description: MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development,… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MRGPRX2, Polyclonal Antibody

Full Product Name

MRGPRX2 antibody - middle region

Product Gene Name

anti-MRGPRX2 antibody

Product Synonym Gene Name

MRGX2

Immunogen Sequence

Synthetic peptide located within the following region: VCVLLWALSL LLSILEGKFC GFLFSDGDSG WCQTFDFITA AWLIFLFMVL

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

MRGPRX2 peptide (MBS3239503) is used for blocking the activity of MRGPRX2 antibody (MBS3214566)

Molecular Weight

37kDa

OMIM

607228

3D Structure

ModBase 3D Structure for Q96LB1

Homology

Human: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human MRGPRX2

Product Categories/Family for anti-MRGPRX2 antibody

Polyclonal; Immunology; GPCR

Applications Tested/Suitable for anti-MRGPRX2 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-MRGPRX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRGPRX2 purchase

MBS3214566 is an antibody targeting MRGPRX2. Also known as MRGPRX2 antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MRGPRX2. It may not necessarily be applicable to this product.

NCBI GI #

16876451

NCBI GeneID

117194

NCBI Accession #

NP_473371

UniProt Primary Accession #

Q96LB1

UniProt Related Accession #

Q96LB1

GenBank Nucleotide #

NM_054030

NCBI Official Full Name

mas-related G-protein coupled receptor member X2

NCBI Official Synonym Full Names

MAS related GPR family member X2

NCBI Official Symbol

MRGPRX2

NCBI Official Synonym Symbols

MGRG3; MRGX2

UniProt Protein Name

Mas-related G-protein coupled receptor member X2

Protein Family

Mas-related G-protein coupled receptor

UniProt Gene Name

MRGPRX2

UniProt Synonym Gene Names

MRGX2

UniProt Entry Name

MRGX2_HUMAN

NCBI Protein Information

mas-related G-protein coupled receptor member X2

UniProt Comments for MRGPRX2

MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; sensory perception of pain; sleep

Research Articles on MRGPRX2

1. Low levels of MRGPRX2 were detected in non-asthma lung mast cells, but its expression was significantly up-regulated in asthma lung mast cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-MRGPRX2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>4 publications with MRGPRX2 and Inflammation
Nervous System Diseases Antibodies	>2 publications with MRGPRX2 and Nervous System Diseases
Adenocarcinoma Antibodies	>1 publications with MRGPRX2 and Adenocarcinoma
Brain Diseases Antibodies	>1 publications with MRGPRX2 and Brain Diseases
Neurologic Manifestations Antibodies	>1 publications with MRGPRX2 and Neurologic Manifestations
Lung Diseases Antibodies	>1 publications with MRGPRX2 and Lung Diseases

Organs/Tissues associated with anti-MRGPRX2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with MRGPRX2 and Brain
Testis Antibodies	>2 publications with MRGPRX2 and Testis
Bone Marrow Antibodies	>1 publications with MRGPRX2 and Bone Marrow