PLA2G4B Antibody – Rabbit Polyclonal

This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]

PLA2G4B: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Not inhibited by pyrrolidine-2 and Wyeth-1. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 translocates to membrane vesicles in a calcium-dependent fashion and has activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.

Protein type: Phospholipase; EC 3.1.1.4; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 15q11.2-q21.3

Cellular Component: early endosome membrane; mitochondrial inner membrane; extracellular region; cytosol

Molecular Function: calcium-dependent phospholipid binding; calcium-dependent phospholipase A2 activity; calcium ion binding; lysophospholipase activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; glycerophospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; calcium-mediated signaling; arachidonic acid metabolic process; phosphatidic acid biosynthetic process; parturition; inflammatory response