Rabbit Anti-YTHDF2 Polyclonal Antibody – Cat# MBS3217657

Host: Rabbit
Target Name: YTHDF2
Sample Type: MCF7 Whole Cell lysates
Antibody Dilution: 1.0ug/ml

YTHDF2 Antibody – Rabbit Polyclonal

Name: YTHDF2 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3217657
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3217657

This is a rabbit polyclonal antibody against YTHDF2. It was validated on Western BlotTarget Description: This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

YTHDF2, Polyclonal Antibody

Full Product Name

YTHDF2 Antibody - C-terminal region

Product Gene Name

anti-YTHDF2 antibody

Product Synonym Gene Name

HGRG8; NY-REN-2

Immunogen Sequence

Synthetic peptide located within the following region: WSQDKWKGRF DVRWIFVKDV PNSQLRHIRL ENNENKPVTN SRDTQEVPLE

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

YTHDF2 peptide (MBS3242553) is used for blocking the activity of YTHDF2 antibody (MBS3217657)

Molecular Weight

58kDa

OMIM

610640

3D Structure

ModBase 3D Structure for Q9Y5A9

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human YTHDF2

Product Categories/Family for anti-YTHDF2 antibody

Polyclonal; Cancer; Signal Transduction; Disease Related; DNA/RNA/Protein Interactions

Applications Tested/Suitable for anti-YTHDF2 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-YTHDF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YTHDF2 purchase

MBS3217657 is an antibody targeting YTHDF2. Also known as YTHDF2 Antibody - C-terminal region. Reactive in Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for YTHDF2. It may not necessarily be applicable to this product.

NCBI GI #

116812575

NCBI GeneID

51441

NCBI Accession #

NP_057342

UniProt Primary Accession #

Q9Y5A9

UniProt Related Accession #

Q9Y5A9

GenBank Nucleotide #

NM_016258

NCBI Official Full Name

YTH domain-containing family protein 2 isoform 1

NCBI Official Synonym Full Names

YTH N6-methyladenosine RNA binding protein 2

NCBI Official Symbol

YTHDF2

NCBI Official Synonym Symbols

CAHL; HGRG8; NY-REN-2

UniProt Protein Name

YTH domain-containing family protein 2

UniProt Synonym Protein Names

CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2

Protein Family

YTH domain-containing family protein

UniProt Gene Name

YTHDF2

UniProt Synonym Gene Names

HGRG8

UniProt Entry Name

YTHD2_HUMAN

NCBI Protein Information

YTH domain-containing family protein 2

NCBI Summary for YTHDF2

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Research Articles on YTHDF2

1. YTHDF2 recruits the CCR4-NOT complex through a direct interaction between the YTHDF2 N-terminal region and the SH domain of the CNOT1 subunit, and that this recruitment is essential for the deadenylation of m6A-containing RNAs by CAF1 and CCR4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.