• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GAD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3220833

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GAD2, Polyclonal Antibody
Full Product Name
GAD2 Antibody - N-terminal region
Product Gene Name
anti-GAD2 antibody
Product Synonym Gene Name
GAD65
Immunogen Sequence
Synthetic peptide located within the following region: FWSFGSEDGS GDSENPGTAR AWCQVAQKFT GGIGNKLCAL LYGDAEKPAE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GAD2 peptide (MBS3245630) is used for blocking the activity of GAD2 antibody (MBS3220833)
Molecular Weight
65 kDa
OMIM
138275
3D Structure
ModBase 3D Structure for Q05329
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GAD2

Product Categories/Family for anti-GAD2 antibody

Polyclonal
Applications Tested/Suitable for anti-GAD2 antibody
Western Blot (WB)

Western Blot (WB) of anti-GAD2 antibody

Host: Rabbit
Target Name: GAD2
Sample Tissue: Human HCT116 Whole Cell
Antibody Dilution: 1.0ug/ml
Rabbit Anti-GAD2 Polyclonal Antibody – Cat# MBS3220833

Other Notes

Small volumes of anti-GAD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAD2 purchase

MBS3220833 is an antibody targeting GAD2. Also known as GAD2 Antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GAD2. It may not necessarily be applicable to this product.

NCBI GI #
4503875
NCBI GeneID
2572
NCBI Accession #
NP_000809.1
UniProt Primary Accession #
Q05329
UniProt Related Accession #
Q05329
GenBank Nucleotide #
NM_000818.2
NCBI Official Full Name
glutamate decarboxylase 2
NCBI Official Synonym Full Names
glutamate decarboxylase 2
NCBI Official Symbol
GAD2
NCBI Official Synonym Symbols
GAD65
UniProt Protein Name
Glutamate decarboxylase 2
UniProt Synonym Protein Names
65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
Protein Family
Glutamate decarboxylase
UniProt Gene Name
GAD2
UniProt Synonym Gene Names
GAD65; GAD-65
UniProt Entry Name
DCE2_HUMAN
NCBI Protein Information
glutamate decarboxylase 2

UniProt Comments for GAD2

GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Lyase; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 10p11.23

Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; axon; perinuclear region of cytoplasm; plasma membrane; cytosol; cell junction

Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process
Show more

Research Articles on GAD2

1. In individuals with adult-onset diabetes, presence of N-terminally truncated GAD65 autoantibodies is associated with the clinical phenotype of autoimmune type 1 diabetes and predicts insulin therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GAD2 antibody

 Reference Product  PubMed Publications
 GAD1 antibody  >48 publications with GAD2 and GAD1
 GLUL antibody  >1 publications with GAD2 and GLUL
 INS antibody  >1 publications with GAD2 and INS
 SLC32A1 antibody  >1 publications with GAD2 and SLC32A1
 ABAT antibody  >1 publications with GAD2 and ABAT

Pathways associated with anti-GAD2 antibody

 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram

Diseases associated with anti-GAD2 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >18 publications with GAD2 and Mental Disorders
 Nervous System Diseases Antibodies  >12 publications with GAD2 and Nervous System Diseases
 Brain Diseases Antibodies  >10 publications with GAD2 and Brain Diseases
 Schizophrenia Antibodies  >9 publications with GAD2 and Schizophrenia
 Epilepsy Antibodies  >6 publications with GAD2 and Epilepsy
 Seizures Antibodies  >6 publications with GAD2 and Seizures
 Inflammation Antibodies  >4 publications with GAD2 and Inflammation
 Depressive Disorder Antibodies  >3 publications with GAD2 and Depressive Disorder
 Movement Disorders Antibodies  >2 publications with GAD2 and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >2 publications with GAD2 and Substance Withdrawal Syndrome

Organs/Tissues associated with anti-GAD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with GAD2 and Brain
 Pancreas Antibodies  >3 publications with GAD2 and Pancreas
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000