RGS14 Antibody – Rabbit Polyclonal

RGS14: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: spindle pole; centrosome; microtubule; PML body; dendrite; postsynaptic density; dendritic spine; nuclear body; postsynaptic membrane; cytoplasm; plasma membrane; spindle; nucleus; cell junction

Molecular Function: receptor signaling complex scaffold activity; microtubule binding; GDP-dissociation inhibitor activity; receptor signaling protein activity; GTPase activating protein binding; G-protein alpha-subunit binding; protein kinase binding; GTPase activator activity

Biological Process: regulation of transcription in response to stress; negative regulation of MAP kinase activity; mitosis; zygote asymmetric cell division; positive regulation of neurogenesis; negative regulation of synaptic plasticity; platelet-derived growth factor receptor signaling pathway; nucleocytoplasmic transport; learning; spindle organization and biogenesis; chromosome segregation; long-term memory; cell division; visual learning; response to oxidative stress; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity