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CDC14B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222515

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CDC14B, Polyclonal Antibody
Full Product Name
CDC14B Antibody - middle region
Product Gene Name
anti-CDC14B antibody
Product Synonym Gene Name
CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
Immunogen Sequence
Synthetic peptide located within the following region: FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR FIAFCGPHSR ARLESGYHQH
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CDC14B peptide (MBS3247183) is used for blocking the activity of CDC14B antibody (MBS3222515)
Molecular Weight
50 kDa
OMIM
603505
3D Structure
ModBase 3D Structure for O60729
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CDC14B

Product Categories/Family for anti-CDC14B antibody

Polyclonal; Apoptosis; DNA/RNA/Protein Interactions; Meiosis/Mitosis/Cell Cycle
Applications Tested/Suitable for anti-CDC14B antibody
Western Blot (WB)

Western Blot (WB) of anti-CDC14B antibody

Host: Rabbit
Target Name: CDC14B
Sample Tissue: Human HT1080 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-CDC14B Polyclonal Antibody – Cat# MBS3222515

Other Notes

Small volumes of anti-CDC14B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC14B purchase

MBS3222515 is an antibody targeting CDC14B. Also known as CDC14B Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC14B. It may not necessarily be applicable to this product.

NCBI GI #
116008458
NCBI GeneID
8555
NCBI Accession #
NP_001070649.1
UniProt Primary Accession #
O60729
UniProt Related Accession #
O60729
GenBank Nucleotide #
NM_001077181.1
NCBI Official Full Name
dual specificity protein phosphatase CDC14B isoform 3
NCBI Official Synonym Full Names
cell division cycle 14B
NCBI Official Symbol
CDC14B
NCBI Official Synonym Symbols
CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
UniProt Protein Name
Dual specificity protein phosphatase CDC14B
UniProt Synonym Protein Names
CDC14 cell division cycle 14 homolog B
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
CDC14B
UniProt Entry Name
CC14B_HUMAN
NCBI Protein Information
dual specificity protein phosphatase CDC14B

UniProt Comments for CDC14B

CDC14B: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Nucleolus; EC 3.1.3.16; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: nucleoplasm; nuclear membrane; nucleolus; nucleus

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity

Biological Process: anaphase-promoting complex activation; protein amino acid dephosphorylation; G2/M transition DNA damage checkpoint; DNA repair
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Research Articles on CDC14B

1. The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDC14B antibody

 Reference Product  PubMed Publications
 SIRT2 antibody  >2 publications with CDC14B and SIRT2

Pathways associated with anti-CDC14B antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram

Diseases associated with anti-CDC14B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with CDC14B and Neoplasms
 Liver Diseases Antibodies  >2 publications with CDC14B and Liver Diseases
 Skin Diseases Antibodies  >1 publications with CDC14B and Skin Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CDC14B and Carcinoma, Hepatocellular
 Anemia Antibodies  >1 publications with CDC14B and Anemia
 Adenocarcinoma Antibodies  >1 publications with CDC14B and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with CDC14B and Breast Neoplasms
 Nervous System Diseases Antibodies  >1 publications with CDC14B and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with CDC14B and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with CDC14B and Liver Neoplasms

Organs/Tissues associated with anti-CDC14B antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CDC14B and Liver
 Kidney Antibodies  >2 publications with CDC14B and Kidney
 Brain Antibodies  >2 publications with CDC14B and Brain
 Vascular Antibodies  >1 publications with CDC14B and Vascular
 Skin Antibodies  >1 publications with CDC14B and Skin
 Testis Antibodies  >1 publications with CDC14B and Testis
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