Prostaglandin D Synthase (PGDS) ELISA Kit for Rat

Name: Rat PGDS ELISA Kit; Prostaglandin D Synthase; MyBioSource
Brand: MyBioSource
SKU: MBS034976
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS034976

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of PGDS (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Prostaglandin D Synthase (PGDS), ELISA Kit

Full Product Name

Rat Prostaglandin D Synthase ELISA Kit

Product Gene Name

PGDS elisa kit

Species Reactivity

Rat

Assay Type

Quantitative Sandwich

Detection Range

3.12ng/ml-100ng/ml

Sensitivity

1.0ng/ml

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

23,344 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (95219707..95264027, complement). Location: 4q22.3

OMIM

602598

3D Structure

ModBase 3D Structure for O60760

Other Notes

Small volumes of PGDS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGDS purchase

MBS034976 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Prostaglandin D Synthase (PGDS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PGDS. The ELISA analytical biochemical technique of the MBS034976 kit is based on PGDS antibody-PGDS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PGDS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PGDS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PGDS. It may not necessarily be applicable to this product.

NCBI GI #

49456319

NCBI GeneID

27306

NCBI Accession #

CAG46480.1

UniProt Primary Accession #

O60760

UniProt Secondary Accession #

Q6FHT9

UniProt Related Accession #

O60760

NCBI Official Full Name

PGDS

NCBI Official Synonym Full Names

hematopoietic prostaglandin D synthase

NCBI Official Symbol

HPGDS

NCBI Official Synonym Symbols

GSTS; PGD2; PGDS; GSTS1-1

UniProt Protein Name

Hematopoietic prostaglandin D synthase

UniProt Synonym Protein Names

GST class-sigma; Glutathione S-transferase (EC:2.5.1.18); Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase

Protein Family

Gamma-DL-glutamyl hydrolase

UniProt Gene Name

HPGDS

UniProt Synonym Gene Names

GSTS; PGDS; PTGDS2; H-PGDS

UniProt Entry Name

HPGDS_HUMAN

NCBI Protein Information

hematopoietic prostaglandin D synthase; GST class-sigma; prostaglandin-H2 D-isomerase; glutathione S-transferase sigma; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; hematopoietic prostaglandin D2 synthase; glutathione-requiring prostaglandin D synthase

NCBI Summary for PGDS

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

UniProt Comments for PGDS

Ptgds2: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family.

Protein type: EC 5.3.99.2; EC 2.5.1.18; Lipid Metabolism - arachidonic acid; Isomerase

Chromosomal Location of Human Ortholog: 4q22.3

Cellular Component: cytoplasm; cytosol

Molecular Function: prostaglandin-D synthase activity; protein homodimerization activity; glutathione transferase activity; magnesium ion binding; calcium ion binding

Biological Process: xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; locomotory behavior; signal transduction; prostaglandin metabolic process

Research Articles on PGDS

1. the Val187Ile HPGDS isoenzyme common among African Americans is not associated with colorectal cancer risk

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGDS elisa kit

Reference Product	PubMed Publications
PTGS2 elisa kit	>11 publications with PGDS and PTGS2
PTGS1 elisa kit	>7 publications with PGDS and PTGS1
PTGIS elisa kit	>1 publications with PGDS and PTGIS
AKR1C3 elisa kit	>1 publications with PGDS and AKR1C3
PTGDS elisa kit	>1 publications with PGDS and PTGDS
PTGES2 elisa kit	>1 publications with PGDS and PTGES2
TBXAS1 elisa kit	>1 publications with PGDS and TBXAS1
PTGES elisa kit	>1 publications with PGDS and PTGES

Pathways associated with PGDS elisa kit

Products by Pathway	Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
C20 Prostanoid Biosynthesis Pathway antibodies	C20 Prostanoid Biosynthesis Pathway Diagram
Glutathione Conjugation Pathway antibodies	Glutathione Conjugation Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Phase II Conjugation Pathway antibodies	Phase II Conjugation Pathway Diagram

Diseases associated with PGDS elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>11 publications with PGDS and Inflammation
Nervous System Diseases Antibodies	>6 publications with PGDS and Nervous System Diseases
Neoplasms Antibodies	>6 publications with PGDS and Neoplasms
Disease Models, Animal Antibodies	>5 publications with PGDS and Disease Models, Animal
Necrosis Antibodies	>2 publications with PGDS and Necrosis
Drug Toxicity Antibodies	>2 publications with PGDS and Drug Toxicity
Cardiovascular Diseases Antibodies	>2 publications with PGDS and Cardiovascular Diseases
Prenatal Exposure Delayed Effects Antibodies	>1 publications with PGDS and Prenatal Exposure Delayed Effects
Neoplasms, Experimental Antibodies	>1 publications with PGDS and Neoplasms, Experimental
Edema Antibodies	>1 publications with PGDS and Edema

Organs/Tissues associated with PGDS elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with PGDS and Blood
Brain Antibodies	>6 publications with PGDS and Brain
Connective Tissue Antibodies	>1 publications with PGDS and Connective Tissue
Placenta Antibodies	>1 publications with PGDS and Placenta