Cadherin EGF LAG Seven-Pass G-Type Receptor 2, CELSR2 (CELSR2) Antibody – Rabbit Polyclonal

Function: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in the CNS and in the eye. Ref.3

Developmental stage: Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed within the anterior neural ectoderm. At E10, expression is strong in the ventricular zones (VZ) in all sectors of the brain, and lower in the marginal zones (MZ). Between E12 and E15, expression is prominant in the brain. It is strong in VZ, lower in MZ, except in telecephalic MZ where it is predominant. The intensity is higher in all VZ, and lower in differentiating fields than in VZ, except in the cerebral hemispheres, and to a lesser extent in the tectum and cerebellum. A weak expression is also observed in the fetal lungs, kidney and epithelia. In the newborn and postnatal stages, expression remains restricted to the VZ as well as in migrating and postmigratory cells throughout the brain. Ref.5

Post-translational modification: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Contains 9 cadherin domains.Contains 7 EGF-like domains.Contains 1 GPS domain.Contains 1 laminin EGF-like domain.Contains 2 laminin G-like domains.