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Glypican-3, GPC3 (GPC3) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355601

Recombinant full length human GPC3 protein.Glypican 3, GPC3 is a member of the glypican family that are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage.… More details

$1215 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glypican-3, GPC3, Recombinant Protein
Full Product Name
Glypican-3, GPC3 Protein (Active)
Product Gene Name
Host
E Coli
Form/Format
Liquid
Preparation and Storage
Ship at 4 degree C. Upon receipt, store at -20 degree C or -80 degree C for 2 years. After reconstituting, it can store at 4 degree C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles.
Molecular Weight
67,049 Da
Chromosome Location
Chromosome: X; NC_005120.3 (139625383..139993328, complement). Location: Xq36
3D Structure
ModBase 3D Structure for P13265
Storage Buffer
Each vial contains 10 mM Tris-HCL (pH8.8 ± 0.2) with 0.05% sodium azide.
Applications Tested/Suitable for GPC3 recombinant protein
ELISA (EIA), SDS-PAGE

Product References and Citations for GPC3 recombinant protein

1. Pilia, G., Hughes-Benzie, R. M., MacKenzie, A., Baybayan, P., Chen, E. Y., Huber, R., Neri, G., Cao, A., Forabosco, A., Schlessinger, D. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nature Genet. 12: 241-247, 1996. 2. Capurro, M. I., Xu, P., Shi, W., Li, F., Jia, A., Filmus, J. Glypican-3 inhibits Hedgehog signaling during development by competing with Patched for Hedgehog binding. Dev. Cell 14: 700-711, 2008.

Other Notes

Small volumes of GPC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPC3 purchase

MBS355601 is a recombinant protein targeting GPC3. Also known as Glypican-3, GPC3 Protein (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GPC3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glypican-3
NCBI Official Synonym Full Names
glypican 3
NCBI Official Symbol
Gpc3
NCBI Official Synonym Symbols
OCI-5
UniProt Protein Name
Glypican-3
UniProt Synonym Protein Names
Intestinal protein OCI-5
Protein Family
UniProt Gene Name
Gpc3
UniProt Entry Name
GPC3_RAT
NCBI Protein Information
glypican-3; proteoglycan GPC3; intestinal protein OCI-5; defective in Simpson-Golabi-Behmel overgrowth syndrome

NCBI Summary for GPC3

heparan sulfate cell surface proteogycan, may be involved in development of mesodermal tissues, may modulate Igf2 function [RGD, Feb 2006]

UniProt Comments for GPC3

Function: Inhibits the dipeptidyl peptidase activity of DPP4

By similarity. Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

Subunit structure: Interacts with DPP4

By similarity.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side. Secreted.

Tissue specificity: Fetal tissues and adult lung.

Sequence similarities: Belongs to the glypican family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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