DKK1 Recombinant Protein

Recombinant full length human DKK1 protein with molecular weight 35 kDa.
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. DKK1 is one of the most upregulated genes in androgen potentiated balding, with DKK-1 messenger RNA upregulated a 3-6 hours after DHT treatment of hair follicles at the dermal papilla in vitro. DKK-1 expression is attenuated by L-threonate in vitro, with the latter a metabolite of ascorbate. DKK-1 gene is transcriptionally silenced by CpG island promoter hypermethylation in colon cancer cell lines, whereas treatment with the DNA-demethylating agent 5-aza-2-deoxycytidine restored DKK-1 expression. In primary colorectal tumors, DKK-1 was found hypermethylated in 17% of cases. Furthermore, while for both secreted frizzled-related proteins (sFRPs) and Wnt inhibitory factor-1 (WIF-1) methylation-associated silencing occurred across the whole spectrum of colorectal tumorigenesis, DKK-1 promoter was selectively hypermethylated in advanced colorectal neoplasms (Duke's C and D tumors).

1. Kwack, M. H.; Sung, Y. K.; Chung, E. J.; Im, S. U.; Ahn, J. S.; Kim, M. K.; Kim, J. C. (2007). "Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes". Journal of Investigative Dermatology 128 (2): 262-269. 2. Kwack, M. H.; Ahn, J. S.; Kim, M. K.; Kim, J. C.; Sung, Y. K. (2010). "Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells". BMB Reports 43 (10): 688-692. 3. Aguilera O,Fraga MF, Ballestar E, et al. (2006). "Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer". Oncogene 25 (29): 4116-21.

Small volumes of DKK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355611 is a recombinant protein targeting DKK1. Also known as DKK1 Protein (Active). Host: E Coli.