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IL21 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9126842
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This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL21, Polyclonal Antibody
Full Product Name
IL21 Polyclonal Antibody
Product Gene Name
anti-IL21 antibody
Product Synonym Names
Za11; IL-21; CVID11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Molecular Weight
155
OMIM
gene 615767
3D Structure
ModBase 3D Structure for Q9HBE4
Species
Human
Immunogen
Recombinant protein of human IL21
Calculated Molecular Weight
18kDa

Product Categories/Family for anti-IL21 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IL21 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-IL21 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-IL21 antibody

Western blot analysis of extracts of various cell lines, using IL21 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
Rabbit Anti-IL21 Polyclonal Antibody – Cat# MBS9126842

Immunohistochemistry (IHC) of anti-IL21 antibody

Immunohistochemistry of paraffin-embedded rat spleen using IL21 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-IL21 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9126842

Other Notes

Small volumes of anti-IL21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL21 purchase

MBS9126842 is an antibody targeting IL21. Also known as IL21 Polyclonal Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL21. It may not necessarily be applicable to this product.

NCBI GI #
55976599
NCBI GeneID
59067
NCBI Accession #
Q9HBE4.2
UniProt Primary Accession #
Q9HBE4
UniProt Secondary Accession #
A5J0L4
UniProt Related Accession #
Q9HBE4
NCBI Official Full Name
Interleukin-21
NCBI Official Synonym Full Names
interleukin 21
NCBI Official Symbol
IL21
NCBI Official Synonym Symbols
Za11; IL-21; CVID11
UniProt Protein Name
Interleukin-21
UniProt Synonym Protein Names
Za11
Protein Family
Interleukin
UniProt Gene Name
IL21
UniProt Synonym Gene Names
IL-21
UniProt Entry Name
IL21_HUMAN
NCBI Protein Information
interleukin-21; interleukin-21 isoform

UniProt Comments for IL21

IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Cell development/differentiation; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tissue remodeling; positive regulation of cell proliferation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response

Disease: Immunodeficiency, Common Variable, 11
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Research Articles on IL21

1. IL-21 receptor has a role in human tendinopathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL21 antibody

 Reference Product  PubMed Publications
 IL21R antibody  >371 publications with IL21 and IL21R
 STAT3 antibody  >116 publications with IL21 and STAT3
 IL15 antibody  >83 publications with IL21 and IL15
 IL4 antibody  >14 publications with IL21 and IL4
 IL13 antibody  >6 publications with IL21 and IL13
 IL9 antibody  >4 publications with IL21 and IL9
 IL7 antibody  >4 publications with IL21 and IL7
 NFATC2 antibody  >1 publications with IL21 and NFATC2
 TSLP antibody  >1 publications with IL21 and TSLP

Pathways associated with anti-IL21 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL21 antibody

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >269 publications with IL21 and Autoimmune Diseases
 Inflammation Antibodies  >174 publications with IL21 and Inflammation
 Lupus Erythematosus, Systemic Antibodies  >72 publications with IL21 and Lupus Erythematosus, Systemic
 Skin Diseases Antibodies  >66 publications with IL21 and Skin Diseases
 Necrosis Antibodies  >62 publications with IL21 and Necrosis
 Liver Diseases Antibodies  >44 publications with IL21 and Liver Diseases
 Celiac Disease Antibodies  >32 publications with IL21 and Celiac Disease
 Hypersensitivity Antibodies  >29 publications with IL21 and Hypersensitivity
 Kidney Diseases Antibodies  >27 publications with IL21 and Kidney Diseases
 Heart Diseases Antibodies  >16 publications with IL21 and Heart Diseases

Organs/Tissues associated with anti-IL21 antibody

 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >1 publications with IL21 and Uncharacterized Tissue
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