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Volixibat (SHP-626)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600116

A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH). More details

$875 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Volixibat, Biochemical
Full Product Name
Volixibat
Product Synonym Names
SHP-626; SAR-548304; LUM-002
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
805.96
Target
ASBT Transporter
Receptor
ASBT Transporter
Chemical Name
N-[3-[(3S, 4R, 5R)-3-Butyl-7-(dimethylamino)-3-ethyl-2, 3, 4, 5-tetrahydro-4-hydroxy-1, 1-dioxido-1-benzothiepin-5-yl]phenyl]-N'-[3-O-(phenylmethyl)-6-O-sulfo-beta-D-glucopyranosyl]urea
SMILES
O=C(NC1=CC=CC([C@H](C2=CC(N(C)C)=CC=C23)[C@@H](O)[C@](CC)(CCCC)CS3(=O)=O)=C1)N[C@H]4[C@@H]([C@H]([C@@H]([C@@H](COS(=O)(O)=O)O4)O)OCC5=CC=CC=C5)O
Molecular Formula
C38H51N3O12S2
CAS Number
1025216-57-2

Product Categories/Family for Volixibat biochemical

Steatohepatitis; Membrane Transporter/Ion Channel; Other Indications

Structure of Volixibat biochemical

Volixibat SHP-626 Biochemical – Cat# MBS3600116

Product References and Citations for Volixibat biochemical

1. Siebers N, et al. Eur J Drug Metab Pharmacokinet. 2017 Jul 12. doi: 10.1007/s13318-017-0429-7.
2. Tiessen RG, et al. BMC Gastroenterol. 2018 Jan 5; 18 (1):3.

Other Notes

Small volumes of Volixibat biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Volixibat purchase

MBS3600116 is a biochemical targeting Volixibat.
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