Gemin 2 Antibody – Mouse Monoclonal

MBS375136 is an antibody targeting Gemin 2. Also known as Mouse Anti-Gemin 2 [2E17]. Reactive in Mouse, Human, Xenopus laevis. Host: Mouse.

The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Liu Q (Cell,Sep 1997)PUBMED Sanchez G et al. A novel function for the survival motoneuron protein as a translational regulator. Hum Mol Genet : (2012)PUBMED Wu CY et al. Proteomic assessment of a cell model of spinal muscular atrophy. BMC Neurosci 12:25 (2011). WB ; MousePUBMED Takizawa Y et al. GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res. 2010 Aug;38(15):5059-74. doi: 10.1093/nar/gkq271. Epub 2010 Apr 19. WB; HumanPMID: 20403813 Burnett BG et al. Regulation of SMN protein stability. Mol Cell Biol 29:1107-15 (2009). WB ; HumanPUBMED Walker MP et al. SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet 17:3399-410 (2008). ICC/IF ; MousePUBMED Morency E et al. A novel cell response triggered by interphase centromere structural instability. J Cell Biol 177:757-68 (2007). ICC/IF ; HumanPUBMED Renvois© B et al. Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells. J Cell Sci 119:680-92 (2006)PUBMED

Small volumes of anti-Gemin 2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.