Nesprin 2 (SYNE2) Antibody – Mouse

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

SYNE2: a nuclear transmembrane protein involved in the maintenance of nuclear organization and structural integrity. The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Nine alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: nuclear outer membrane; filopodium membrane; intermediate filament cytoskeleton; nuclear membrane; sarcoplasmic reticulum membrane; nuclear lumen; focal adhesion; mitochondrion; sarcoplasmic reticulum; integral to membrane; nuclear envelope; Z disc; nucleoplasm; cytoplasm; nucleus

Molecular Function: actin filament binding; protein binding; actin binding

Biological Process: centrosome localization; establishment and/or maintenance of cell polarity; nuclear migration along microfilament; nuclear migration; nuclear membrane organization and biogenesis; positive regulation of cell migration

Disease: Emery-dreifuss Muscular Dystrophy 5, Autosomal Dominant