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ANP32A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150426

PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in… More details

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Product Overview

Online Datasheet in PDF
Product Name
PHAP (ANP32A), Polyclonal Antibody
Full Product Name
PHAP Antibody
Product Gene Name
anti-ANP32A antibody
Product Synonym Names
PHAP; LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1; LANP; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
PHAP Antibody is DEAE purified.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
PHAP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
PHAP peptide (MBS153142) is used for blocking the activity of PHAP antibody (MBS150426)
Molecular Weight
35 kDa
OMIM
600832
3D Structure
ModBase 3D Structure for P39687
Conjugate
Unconjugated
Immunogen
PHAP antibody was raised with a synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.
Buffer
PHAP Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ANP32A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ANP32A antibody
PHAP antibody can be used for detection of PHAP I and PHAP III by Western blot at 1 mug/mL. At approximately 35 kDa and 32 kDa a band can be detected. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ANP32A antibody

Western blot analysis of PHAP expression in human Raji cell llysate with PHAP antibody at 1 μg/mL.
Rabbit Anti-ANP32A Polyclonal Antibody – Cat# MBS150426

Immunohistochemistry (IHC) of anti-ANP32A antibody

Immunohistochemistry of PHAP in human small intestine tissue with PHAP antibody at 10 μg/mL.
Rabbit Anti-ANP32A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150426

Immunofluorescence (IF) of anti-ANP32A antibody

Immunofluorescence of PHAP in human small intestine tissue with PHAP antibody at 20 μg/mL.
Rabbit Anti-ANP32A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150426

Other Notes

Small volumes of anti-ANP32A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANP32A purchase

MBS150426 is an antibody targeting ANP32A. Also known as PHAP Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANP32A. It may not necessarily be applicable to this product.

NCBI GI #
730318
NCBI GeneID
8125
NCBI Accession #
P39687.1
UniProt Primary Accession #
P39687
UniProt Secondary Accession #
Q53FK4; Q5J8L8; Q7M4N6; B2R6T4
UniProt Related Accession #
P39687
NCBI Official Full Name
Acidic leucine-rich nuclear phosphoprotein 32 family member A
NCBI Official Synonym Full Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
NCBI Official Symbol
ANP32A
NCBI Official Synonym Symbols
LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
UniProt Protein Name
Acidic leucine-rich nuclear phosphoprotein 32 family member A
UniProt Synonym Protein Names
Acidic nuclear phosphoprotein pp32; pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI
Protein Family
Acidic leucine-rich nuclear phosphoprotein 32 family
UniProt Gene Name
ANP32A
UniProt Synonym Gene Names
C15orf1; LANP; MAPM; PHAP1; pp32; LANP; PHAPI
UniProt Entry Name
AN32A_HUMAN
NCBI Protein Information
acidic leucine-rich nuclear phosphoprotein 32 family member A; mapmodulin; hepatopoietin Cn; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; putative HLA-DR-associated protein I; inhibitor-1 of protein phosphatase-2A; cerebellar leucine rich acidic nuclear protein; putative human HLA class II associated protein I; potent heat-stable protein phosphatase 2A inhibitor I1PP2A

UniProt Comments for ANP32A

ANP32A: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. Belongs to the ANP32 family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: nucleoplasm; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleocytoplasmic transport; gene expression
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Research Articles on ANP32A

1. Demonstrate that HPPCn attenuated oxidative injury and fibrosis induced by ethanol feeding and that the SphK1/S1P/S1PRs signalling pathway contributes to this protective effect.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANP32A antibody

 Reference Product  PubMed Publications
 SET antibody  >17 publications with ANP32A and SET
 ELAVL1 antibody  >5 publications with ANP32A and ELAVL1
 MAP1B antibody  >1 publications with ANP32A and MAP1B
 ATXN1 antibody  >1 publications with ANP32A and ATXN1

Pathways associated with anti-ANP32A antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HuR Stabilizes MRNA Pathway antibodies  HuR Stabilizes MRNA Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram

Diseases associated with anti-ANP32A antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >4 publications with ANP32A and Cell Transformation, Neoplastic
 Ataxia Antibodies  >4 publications with ANP32A and Ataxia
 Adenocarcinoma Antibodies  >2 publications with ANP32A and Adenocarcinoma
 Prostatic Diseases Antibodies  >2 publications with ANP32A and Prostatic Diseases
 Liver Diseases Antibodies  >2 publications with ANP32A and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with ANP32A and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with ANP32A and Breast Neoplasms
 Necrosis Antibodies  >2 publications with ANP32A and Necrosis
 Lung Diseases Antibodies  >1 publications with ANP32A and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with ANP32A and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-ANP32A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with ANP32A and Brain
 Nerve Antibodies  >14 publications with ANP32A and Nerve
 Prostate Antibodies  >7 publications with ANP32A and Prostate
 Blood Antibodies  >5 publications with ANP32A and Blood
 Kidney Antibodies  >4 publications with ANP32A and Kidney
 Liver Antibodies  >3 publications with ANP32A and Liver
 Spleen Antibodies  >3 publications with ANP32A and Spleen
 Ovary Antibodies  >3 publications with ANP32A and Ovary
 Pituitary Gland Antibodies  >2 publications with ANP32A and Pituitary Gland
 Pancreas Antibodies  >2 publications with ANP32A and Pancreas
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