Goat Anti-MCM7 Polyclonal Antibody – Cat# MBS3900780

Detection of human and mouse MCM7 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibodies: Affinity purified goat anti-MCM7 antibody MBS3900780 (lot MBS3900780-2) used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

MCM7 Antibody – Goat Polyclonal

Name: MCM7 Antibody; Polyclonal; Goat; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3900780
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3900780

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6,… More details

$250 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCM7, Polyclonal Antibody

Full Product Name

Goat anti-MCM7 Antibody, Affinity Purified

Product Gene Name

anti-MCM7 antibody

Product Synonym Names

homolog of S. cerevisiae Cdc47; P1CDC47; protein phosphatase 1, regulatory subunit 104; PPP1R104; PNAS146; P85MCM; P1.1-MCM3; MCM2; DNA replication licensing factor MCM7; CDC47 homolog; CDC47; minichromosome maintenance deficient 7; DNA replication licensing factor MCM7; minichromosome maintenance complex component 7

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human, Mouse

Form/Format

Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Purity/Purification

Antigen Affinity Purified

Concentration

1000ug/ml (lot specific)

Preparation and Storage

Store at 2-8 degree C
Shelf Life: 1 year from date of receipt

Molecular Weight

60,643 Da

OMIM

600592

3D Structure

ModBase 3D Structure for P33993

Immunogen

Between 300 and 350

Conjugation

Unconjugated

Product Categories/Family for anti-MCM7 antibody

Primary Antibodies

Applications Tested/Suitable for anti-MCM7 antibody

Western Blot (WB)

Application Notes for anti-MCM7 antibody

WB: 1:2000-1:10,000

Other Notes

Small volumes of anti-MCM7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCM7 purchase

MBS3900780 is an antibody targeting MCM7. Also known as Goat anti-MCM7 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM7. It may not necessarily be applicable to this product.

NCBI GI #

33469968

NCBI GeneID

4176

NCBI Accession #

NP_005907.3

UniProt Primary Accession #

P33993

UniProt Secondary Accession #

Q15076; Q96D34; Q96GL1; A4D2A1; A4D2A2; E9PGN9

UniProt Related Accession #

P33993

GenBank Nucleotide #

NM_005916.4

NCBI Official Full Name

DNA replication licensing factor MCM7 isoform 1

NCBI Official Synonym Full Names

minichromosome maintenance complex component 7

NCBI Official Symbol

MCM7

NCBI Official Synonym Symbols

MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3

UniProt Protein Name

DNA replication licensing factor MCM7

UniProt Synonym Protein Names

CDC47 homolog; P1.1-MCM3

Protein Family

DNA replication licensing factor

UniProt Gene Name

MCM7

UniProt Synonym Gene Names

CDC47; MCM2

UniProt Entry Name

MCM7_HUMAN

NCBI Protein Information

DNA replication licensing factor MCM7; CDC47 homolog; homolog of S. cerevisiae Cdc47; minichromosome maintenance deficient 7; protein phosphatase 1, regulatory subunit 104

NCBI Summary for MCM7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Research Articles on MCM7

1. We observed that lower levels of MCM7 correlate with reduced cell proliferation, lower autophagic capacity, and higher intracellular protein abundance phenotypes of aged and systemic sclerosis cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCM7 antibody

Reference Product	PubMed Publications
MCM2 antibody	>133 publications with MCM7 and MCM2
MCM6 antibody	>71 publications with MCM7 and MCM6
MCM4 antibody	>64 publications with MCM7 and MCM4
MCM3 antibody	>51 publications with MCM7 and MCM3
MCM5 antibody	>47 publications with MCM7 and MCM5
CDC6 antibody	>46 publications with MCM7 and CDC6
CDC45 antibody	>43 publications with MCM7 and CDC45
CDC7 antibody	>16 publications with MCM7 and CDC7
MCM10 antibody	>14 publications with MCM7 and MCM10
DBF4 antibody	>11 publications with MCM7 and DBF4

Pathways associated with anti-MCM7 antibody

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with anti-MCM7 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>29 publications with MCM7 and Adenocarcinoma
Prostatic Neoplasms Antibodies	>18 publications with MCM7 and Prostatic Neoplasms
Breast Neoplasms Antibodies	>12 publications with MCM7 and Breast Neoplasms
Disease Models, Animal Antibodies	>11 publications with MCM7 and Disease Models, Animal
Nervous System Diseases Antibodies	>9 publications with MCM7 and Nervous System Diseases
Liver Neoplasms Antibodies	>9 publications with MCM7 and Liver Neoplasms
Cell Transformation, Neoplastic Antibodies	>8 publications with MCM7 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>7 publications with MCM7 and Liver Diseases
Precancerous Conditions Antibodies	>7 publications with MCM7 and Precancerous Conditions
Carcinoma, Hepatocellular Antibodies	>6 publications with MCM7 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-MCM7 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>22 publications with MCM7 and Prostate
Lung Antibodies	>19 publications with MCM7 and Lung
Skin Antibodies	>16 publications with MCM7 and Skin
Blood Antibodies	>14 publications with MCM7 and Blood
Vascular Antibodies	>14 publications with MCM7 and Vascular
Lymph Node Antibodies	>11 publications with MCM7 and Lymph Node
Liver Antibodies	>11 publications with MCM7 and Liver
Lymph Antibodies	>11 publications with MCM7 and Lymph
Muscle Antibodies	>9 publications with MCM7 and Muscle
Brain Antibodies	>9 publications with MCM7 and Brain