Rabbit Anti-PSMC1 Polyclonal Antibody – Cat# MBS3904065

Detection of human and mouse PSMC1 by western blot (h and m) and immunoprecipitation (h). Samples: Whole cell lysate from HEK293T (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), HeLa (H; 50 ug), Jurkat (J; 50 ug) and mouse NIH 3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PSMC1 antibody MBS3904065 used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. PSMC1 was successfully immunoprecipitated by rabbit anti-PSMC1 antibody MBS3904066, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

PSMC1 Antibody – Rabbit Polyclonal

Name: PSMC1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3904065
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904065

Proteasome (prosome, macropain) 26S subunit, ATPase1 (PSMC1) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings… More details

$250 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSMC1, Polyclonal Antibody

Full Product Name

Rabbit anti-PSMC1 Antibody, Affinity Purified

Product Gene Name

anti-PSMC1 antibody

Product Synonym Names

p56; S4; Proteasome 26S subunit ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1; P26S4; 26S proteasome regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S protease regulatory subunit 4; proteasome 26S ATPase subunit 1; 26S protease regulatory subunit 4; proteasome 26S subunit, ATPase 1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Purity/Purification

Antigen Affinity Purified

Concentration

1000ug/ml (lot specific)

Preparation and Storage

Store at 2-8 degree C
Shelf Life: 1 year from date of receipt

Molecular Weight

49,185 Da

OMIM

602706

3D Structure

ModBase 3D Structure for P62191

Predicted Reactivity

Rat, D. melanogaster, Chicken

Immunogen

Between 50 and 100

Conjugation

Unconjugated

Product Categories/Family for anti-PSMC1 antibody

Primary Antibodies

Applications Tested/Suitable for anti-PSMC1 antibody

Western Blot (WB)

Application Notes for anti-PSMC1 antibody

WB: 1:1000-1:5000

Other Notes

Small volumes of anti-PSMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMC1 purchase

MBS3904065 is an antibody targeting PSMC1. Also known as Rabbit anti-PSMC1 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMC1. It may not necessarily be applicable to this product.

NCBI GI #

24430151

NCBI GeneID

5700

NCBI Accession #

NP_002793.2

UniProt Primary Accession #

P62191

UniProt Secondary Accession #

P49014; Q03527; Q6IAW0; Q6NW36; Q96AZ3; B4DR63

UniProt Related Accession #

P62191

GenBank Nucleotide #

NM_002802.2

NCBI Official Full Name

26S protease regulatory subunit 4

NCBI Official Synonym Full Names

proteasome (prosome, macropain) 26S subunit, ATPase, 1

NCBI Official Symbol

PSMC1

NCBI Official Synonym Symbols

S4; p56; P26S4

UniProt Protein Name

26S protease regulatory subunit 4

UniProt Synonym Protein Names

26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1

UniProt Gene Name

PSMC1

UniProt Synonym Gene Names

P26s4

UniProt Entry Name

PRS4_HUMAN

NCBI Protein Information

26S protease regulatory subunit 4; proteasome 26S ATPase subunit 1; proteasome 26S subunit ATPase 1; proteasome 26S subunit, ATPase, 1; 26S proteasome AAA-ATPase subunit RPT2

UniProt Comments for PSMC1

RPT2: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 14q32.11

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; proteasome complex

Molecular Function: ATP binding; ATPase activity; protein binding; TATA-binding protein binding

Biological Process: activation of MAPKK activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; apoptosis; axon guidance; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermal growth factor receptor signaling pathway; ER-associated protein catabolic process; fibroblast growth factor receptor signaling pathway; G1/S transition of mitotic cell cycle; gene expression; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; negative regulation of apoptosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; nerve growth factor receptor signaling pathway; polyamine metabolic process; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; programmed cell death; protein polyubiquitination; Ras protein signal transduction; regulation of amino acid metabolic process; regulation of apoptosis; regulation of mRNA stability; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSMC1 antibody

Reference Product	PubMed Publications
PSMC2 antibody	>1 publications with PSMC1 and PSMC2
PSMA7 antibody	>1 publications with PSMC1 and PSMA7

Pathways associated with anti-PSMC1 antibody

Products by Pathway	Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies	APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram

Diseases associated with anti-PSMC1 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>5 publications with PSMC1 and Brain Diseases
Central Nervous System Diseases Antibodies	>2 publications with PSMC1 and Central Nervous System Diseases
Neoplasms Antibodies	>2 publications with PSMC1 and Neoplasms
Hepatitis Antibodies	>1 publications with PSMC1 and Hepatitis
Liver Diseases Antibodies	>1 publications with PSMC1 and Liver Diseases
Hyperplasia Antibodies	>1 publications with PSMC1 and Hyperplasia

Organs/Tissues associated with anti-PSMC1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with PSMC1 and Brain
Blood Antibodies	>3 publications with PSMC1 and Blood
Muscle Antibodies	>2 publications with PSMC1 and Muscle
Prostate Antibodies	>2 publications with PSMC1 and Prostate
Spleen Antibodies	>1 publications with PSMC1 and Spleen
Liver Antibodies	>1 publications with PSMC1 and Liver
Testis Antibodies	>1 publications with PSMC1 and Testis
Lung Antibodies	>1 publications with PSMC1 and Lung