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c-MYB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904349

c-Myb is a member of the MYB family of transcription factors. C-Myb contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. C-myb plays an essential… More details

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Product Overview

Online Datasheet in PDF
Product Name
c-Myb, Polyclonal Antibody
Full Product Name
Rabbit anti-c-Myb Antibody, Affinity Purified
Product Gene Name
anti-c-Myb antibody
Product Synonym Gene Name
MYB
Product Synonym Names
proto-oncogene c-Myb; transcriptional activator Myb; oncogene AMV; efg; c-myb_CDS; c-myb; Cmyb; v-myb avian myeloblastosis viral oncogene homolog; Transcriptional activator Myb; MYB proto-oncogene, transcription factor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
37,507 Da
OMIM
189990
3D Structure
ModBase 3D Structure for P10242
Immunogen
Between 225 and 275
Conjugation
Unconjugated

Product Categories/Family for anti-c-Myb antibody

Primary Antibodies
Applications Tested/Suitable for anti-c-Myb antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-c-Myb antibody
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-c-Myb antibody

Detection of human c-Myb by immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and salivary gland (right). Antibody: Affinity purified rabbit anti-c-Myb (Cat. No. MBS3904349 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-c-MYB Polyclonal Antibody – Cat# MBS3904349

Immunoprecipitation (IP) of anti-c-Myb antibody

Detection of human c-Myb by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from MOLT-4 cells. Antibodies: Affinity purified rabbit anti-c-Myb antibody MBS3904349 (lot MBS3904349-1) used for IP at 6 ug/mg lysate. c-Myb was also immunoprecipitated by rabbit anti-c-Myb antibodies A304-134A, MBS3904347 and MBS3904348. For blotting immunoprecipitated c-Myb, MBS3904350 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-c-MYB Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904349

Other Notes

Small volumes of anti-c-Myb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for c-Myb purchase

MBS3904349 is an antibody targeting c-Myb. Also known as Rabbit anti-c-Myb Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for c-Myb. It may not necessarily be applicable to this product.

NCBI GI #
46361980
NCBI GeneID
4602
NCBI Accession #
NP_005366.2
UniProt Primary Accession #
P10242
UniProt Secondary Accession #
P78391; P78392; P78525; P78526; Q14023; Q14024; E9PI07; E9PLZ5; E9PNA4; E9PNL6; E9PRS2
UniProt Related Accession #
P10242
GenBank Nucleotide #
NM_005375.2
NCBI Official Full Name
transcriptional activator Myb isoform 2
NCBI Official Synonym Full Names
v-myb avian myeloblastosis viral oncogene homolog
NCBI Official Symbol
MYB
NCBI Official Synonym Symbols
efg; Cmyb; c-myb; c-myb_CDS
UniProt Protein Name
Transcriptional activator Myb
UniProt Synonym Protein Names
Proto-oncogene c-Myb
Protein Family
Cyclin-D-binding Myb-like transcription factor
UniProt Gene Name
MYB
UniProt Entry Name
MYB_HUMAN
NCBI Protein Information
transcriptional activator Myb; c-myb8B_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; proto-oncogene c-Myb; c-myb protein (140 AA)

NCBI Summary for c-Myb

This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
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UniProt Comments for c-Myb

Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: nuclear matrix; cytosol

Molecular Function: protein binding; chromatin binding

Biological Process: positive regulation of histone H3-K9 methylation; thymus development; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; calcium ion transport; B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; embryonic gut development; G1/S transition of mitotic cell cycle
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Research Articles on c-Myb

1. study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene; MYB binds to this new site

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-c-Myb antibody

 Reference Product  PubMed Publications
 MYC antibody  >751 publications with c-Myb and MYC
 CD4 antibody  >42 publications with c-Myb and CD4
 CREBBP antibody  >22 publications with c-Myb and CREBBP
 EP300 antibody  >16 publications with c-Myb and EP300
 SND1 antibody  >7 publications with c-Myb and SND1
 NLK antibody  >5 publications with c-Myb and NLK
 CEBPB antibody  >3 publications with c-Myb and CEBPB

Pathways associated with anti-c-Myb antibody

 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL2 Signaling Events Mediated By PI3K Pathway antibodies  IL2 Signaling Events Mediated By PI3K Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-c-Myb antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >142 publications with c-Myb and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >100 publications with c-Myb and Breast Neoplasms
 Adenocarcinoma Antibodies  >97 publications with c-Myb and Adenocarcinoma
 Anemia Antibodies  >61 publications with c-Myb and Anemia
 Nervous System Diseases Antibodies  >50 publications with c-Myb and Nervous System Diseases
 Carcinoma, Adenoid Cystic Antibodies  >46 publications with c-Myb and Carcinoma, Adenoid Cystic
 Inflammation Antibodies  >46 publications with c-Myb and Inflammation
 Cardiovascular Diseases Antibodies  >44 publications with c-Myb and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >43 publications with c-Myb and Lung Neoplasms
 Necrosis Antibodies  >33 publications with c-Myb and Necrosis

Organs/Tissues associated with anti-c-Myb antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >692 publications with c-Myb and Blood
 Bone Marrow Antibodies  >188 publications with c-Myb and Bone Marrow
 Liver Antibodies  >125 publications with c-Myb and Liver
 Skin Antibodies  >102 publications with c-Myb and Skin
 Thymus Antibodies  >89 publications with c-Myb and Thymus
 Lung Antibodies  >82 publications with c-Myb and Lung
 Kidney Antibodies  >60 publications with c-Myb and Kidney
 Lymph Node Antibodies  >46 publications with c-Myb and Lymph Node
 Salivary Gland Antibodies  >38 publications with c-Myb and Salivary Gland
 Intestine Antibodies  >38 publications with c-Myb and Intestine
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