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Oxytocinase (LNPEP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904552

Oxytocinase is a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the… More details

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Product Overview

Online Datasheet in PDF
Product Name
Oxytocinase (LNPEP), Polyclonal Antibody
Full Product Name
Rabbit anti-Oxytocinase Antibody, Affinity Purified
Product Gene Name
anti-LNPEP antibody
Product Synonym Names
IRAP; PLAP; placental leucine aminopeptidase; oxytocinase; vasopressinase; leucyl-cystinyl aminopeptidase; P-LAP; insulin-regulated membrane aminopeptidase; insulin-regulated aminopeptidase; cystinyl aminopeptidase; CAP; AT (4) receptor; angiotensin IV receptor; insulin-responsive aminopeptidase; otase; Leucyl-cystinyl aminopeptidase; leucyl and cystinyl aminopeptidase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
151300
3D Structure
ModBase 3D Structure for Q9UIQ6
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-LNPEP antibody

Primary Antibodies
Applications Tested/Suitable for anti-LNPEP antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-LNPEP antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-LNPEP antibody

Detection of human Oxytocinase by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-Oxytocinase antibody MBS3904552 (lot MBS3904552-1) used for IP at 6 ug per reaction. Oxytocinase was also immunoprecipitated by rabbit anti-Oxytocinase antibody BL16227. For blotting immunoprecipitated Oxytocinase, MBS3904552 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-LNPEP Polyclonal Antibody – Cat# MBS3904552

Western Blot (WB) of anti-LNPEP antibody

Detection of human Oxytocinase by western blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, HEK293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-Oxytocinase antibody MBS3904552 (lot MBS3904552-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-LNPEP Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904552

Other Notes

Small volumes of anti-LNPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LNPEP purchase

MBS3904552 is an antibody targeting LNPEP. Also known as Rabbit anti-Oxytocinase Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LNPEP. It may not necessarily be applicable to this product.

NCBI GeneID
4012
NCBI Accession #
NP_787116.2
UniProt Primary Accession #
Q9UIQ6
UniProt Protein Name
Leucyl-cystinyl aminopeptidase
UniProt Synonym Protein Names
Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; Oxytocinase; OTase; Placental leucine aminopeptidase
Protein Family
Leucyl-cystinyl aminopeptidase
UniProt Gene Name
LNPEP
UniProt Synonym Gene Names
OTASE; Cystinyl aminopeptidase; IRAP; OTase; P-LAP
UniProt Entry Name
LCAP_HUMAN

UniProt Comments for LNPEP

IRAP: a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described.

Protein type: EC 3.4.11.3; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: cytoplasmic vesicle membrane; membrane; perinuclear region of cytoplasm; lysosomal membrane; integral to plasma membrane; extracellular region; plasma membrane; intracellular; cytosol

Molecular Function: zinc ion binding; metallopeptidase activity; aminopeptidase activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; cell-cell signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein catabolic process; female pregnancy; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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