Mouse Anti-EDG6 Monoclonal Antibody – Cat# MBS395034

Sphingosine 1 Phosphate 4 Receptor (EDG6) Antibody – Mouse Monoclonal

Name: EDG6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395034
Price: 800 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395034

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related… More details

$800 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sphingosine 1 Phosphate 4 Receptor (EDG6), Monoclonal Antibody

Full Product Name

Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6) FITC Conjugate

Product Gene Name

anti-EDG6 antibody

Product Synonym Names

Endothelial cell differentiation gene 6 C-terminal; Sphingosine-1-Phosphate Receptor-4 (S1P4)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

Host

Mouse

Species Reactivity

Human

Form/Format

FITC; Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purity/Purification

Protein A/G Chromatography

Preparation and Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Chromosome Location

Chromosome: 19; NC_000019.9 (3178736..3180330). Location: 19p13.3

OMIM

603751

3D Structure

ModBase 3D Structure for O95977

Immunogen

Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells.

Product Categories/Family for anti-EDG6 antibody

Monoclonal Antibody; G Protein-Coupled Receptors

Applications Tested/Suitable for anti-EDG6 antibody

Western Blot (WB), Flow Cytometry (FC/FACS)

Application Notes for anti-EDG6 antibody

Antibody can be used for flow cytometry (use 1 µg of antibody per 10^6 cells). NOTE: Epitope for the antibody is the C-terminal of the EDG6 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody. Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Flow Cytometry Staining
Positive Control: Not Available

Other Notes

Small volumes of anti-EDG6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDG6 purchase

MBS395034 is an antibody targeting EDG6. Also known as Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6) FITC Conjugate. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for EDG6. It may not necessarily be applicable to this product.

NCBI GI #

4503459

NCBI GeneID

8698

NCBI Accession #

NP_003766.1

UniProt Primary Accession #

O95977

UniProt Secondary Accession #

D6W612

UniProt Related Accession #

O95977

GenBank Nucleotide #

NM_003775.3

NCBI Official Full Name

sphingosine 1-phosphate receptor 4

NCBI Official Synonym Full Names

sphingosine-1-phosphate receptor 4

NCBI Official Symbol

S1PR4

NCBI Official Synonym Symbols

EDG6; LPC1; S1P4; SLP4

UniProt Protein Name

Sphingosine 1-phosphate receptor 4

UniProt Synonym Protein Names

Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6

UniProt Gene Name

S1PR4

UniProt Synonym Gene Names

EDG6; S1P receptor 4; S1P4

UniProt Entry Name

S1PR4_HUMAN

NCBI Protein Information

sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P receptor Edg-6; sphingosine 1-phosphate receptor Edg-6; endothelial differentiation G-protein coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

NCBI Summary for EDG6

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

UniProt Comments for EDG6

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Ref.5 Ref.6

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Research Articles on EDG6

1. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EDG6 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Lysosphingolipid And LPA Receptors Pathway antibodies	Lysosphingolipid And LPA Receptors Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
S1P4 Pathway antibodies	S1P4 Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram