Adiponectin Receptor 1 (ADIPOR1) Antibody – Rabbit Polyclonal

This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012]

Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Ref.8

Subunit structure: May form homomultimer and heteromultimers. Ref.8

Subcellular location: Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.8

Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. Ref.1 Ref.8

Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

Sequence similarities: Belongs to the ADIPOR family.

Sequence caution: The sequence AAD34040.1 differs from that shown. Reason: Frameshift at position 369.