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Sphingosine 1-Phosphate Lyase 1 (SGPL1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395770

Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1-phosphate… More details

$670 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sphingosine 1-Phosphate Lyase 1 (Sgpl1), Polyclonal Antibody
Full Product Name
Sphingosine 1-Phosphate Lyase 1
Product Gene Name
Product Synonym Names
EC 4.1.2.27; SP-lyase; hSPL or Sphingosine-1-phosphate aldolase. Gene name: SGPL1 or KIAA1252
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide
Purity/Purification
Antigen Immunoaffiinity Purification
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
63,758 Da
Chromosome Location
Chromosome: 20; NC_005119.3 (32497280..32543188, complement). Location: 20q11
3D Structure
ModBase 3D Structure for Q8CHN6
Immunogen
Synthetic peptide derived from the sphingosine 1-phosphate lyase 1 protein.
Positive Control
Madin-Darby Bovine Kidney (MDBK) cell lysate(
Applications Tested/Suitable for anti-Sgpl1 antibody
Western Blot (WB)

Western Blot/Blotting of anti-Sgpl1 antibody

Western blot analysis using S1P lyase 1 antibody at a dilution of 1:400 on MDBK cell lysate using mouse anti-rabbit HRP secondary antibody at 1:75,000.
Rabbit Anti-SGPL1 Polyclonal Antibody – Cat# MBS395770

Other Notes

Small volumes of anti-Sgpl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sgpl1 purchase

MBS395770 is an antibody targeting Sgpl1. Also known as Sphingosine 1-Phosphate Lyase 1. Reactive in Human, Mouse, Rat, Bovine. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Sgpl1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sphingosine-1-phosphate lyase 1
NCBI Official Synonym Full Names
sphingosine-1-phosphate lyase 1
NCBI Official Symbol
Sgpl1
NCBI Official Synonym Symbols
spl; S1PL; Spgl1
UniProt Protein Name
Sphingosine-1-phosphate lyase 1
UniProt Synonym Protein Names
Sphingosine-1-phosphate aldolase
UniProt Gene Name
Sgpl1
UniProt Synonym Gene Names
Spl; S1PL; SP-lyase 1; SPL; SPL 1
UniProt Entry Name
SGPL1_RAT
NCBI Protein Information
sphingosine-1-phosphate lyase 1; SPL 1; SP-lyase 1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase

NCBI Summary for Sgpl1

catalyzes the conversion of phosphorylated long chain bases into ethanolamine phosphate and a fatty aldehyde in sphingolipid catabolism [RGD, Feb 2006]

UniProt Comments for Sgpl1

Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis

By similarity.

Catalytic activity: Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

Cofactor: Pyridoxal phosphate

By similarity.

Pathway: Lipid metabolism; sphingolipid metabolism.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type III membrane protein

By similarity.

Sequence similarities: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Sgpl1 antibody

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