Sheep Anti-C-TAK1 Polyclonal Antibody – Cat# MBS395789

Western blot analysis

C-TAK1 Antibody – Sheep Polyclonal

Name: C-TAK1 Antibody; Polyclonal; Sheep; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395789
Price: 500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395789

C-TAK1 (Cdc25C associated protein kinase) is a ubiquitously expressed protein kinase found in human tissues and cell lines and can phosphorylate Cdc25C on serine 216 in vitro. C-TAK1 is distinct from the DNA damage checkpoint kinase Chk1 and may regulate… More details

$500 / 0.25 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C-TAK1, Polyclonal Antibody

Full Product Name

C-TAK1

Product Gene Name

anti-C-TAK1 antibody

Product Synonym Names

Mark3; Sheep anti-Cdc25c associated protein kinase-1; human

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Human

Form/Format

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purity/Purification

Ammonium Sulfate Precipitation

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

Chromosome Location

Chromosome: 14; NC_000014.8 (103851701..103970168). Location: 14q32.3

OMIM

602678

3D Structure

ModBase 3D Structure for P27448

Immunogen

Recombinant, full-length His-tagged human C-TAK1 produced in E. Coli.

Positive Control

Recombinant His-tagged C-TAK1 protein

Product Categories/Family for anti-C-TAK1 antibody

Polyclonal Antibody; Protein Kinases

Applications Tested/Suitable for anti-C-TAK1 antibody

Immunoprecipitation (IP), Western Blot (WB)

Other Notes

Small volumes of anti-C-TAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C-TAK1 purchase

MBS395789 is an antibody targeting C-TAK1. Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for C-TAK1. It may not necessarily be applicable to this product.

NCBI GI #

193083125

NCBI GeneID

4140

NCBI Accession #

NP_001122390.1

UniProt Primary Accession #

P27448

UniProt Secondary Accession #

O60219; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34

UniProt Related Accession #

P27448

GenBank Nucleotide #

NM_001128918.1

NCBI Official Full Name

MAP/microtubule affinity-regulating kinase 3 isoform a

NCBI Official Synonym Full Names

MAP/microtubule affinity-regulating kinase 3

NCBI Official Symbol

MARK3

NCBI Official Synonym Symbols

KP78; CTAK1; PAR1A; Par-1a

UniProt Protein Name

MAP/microtubule affinity-regulating kinase 3

UniProt Synonym Protein Names

C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78

Protein Family

TGF-beta-activated kinase 1 and MAP3K7-binding protein

UniProt Gene Name

MARK3

UniProt Synonym Gene Names

CTAK1; EMK2; cTAK1; EMK-2; Par-1a

UniProt Entry Name

MARK3_HUMAN

NCBI Protein Information

MAP/microtubule affinity-regulating kinase 3; EMK-2; C-TAK1; ELKL motif kinase 2; protein kinase STK10; ser/Thr protein kinase PAR-1; cdc25C-associated protein kinase 1; serine/threonine-protein kinase p78

NCBI Summary for C-TAK1

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for C-TAK1

Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Ref.12

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564. Ref.11

Subcellular location: Cell membrane; Peripheral membrane protein Ref.18.

Tissue specificity: Ubiquitous.

Post-translational modification: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity. Ref.10 Ref.11

Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Contains 1 KA1 (kinase-associated) domain.Contains 1 protein kinase domain.Contains 1 UBA domain.

Research Articles on C-TAK1

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-C-TAK1 antibody

Reference Product	PubMed Publications
MARK2 antibody	>10 publications with C-TAK1 and MARK2
CDC25C antibody	>8 publications with C-TAK1 and CDC25C
KSR1 antibody	>2 publications with C-TAK1 and KSR1
MITF antibody	>1 publications with C-TAK1 and MITF

Diseases associated with anti-C-TAK1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with C-TAK1 and Nervous System Diseases
Adenocarcinoma Antibodies	>3 publications with C-TAK1 and Adenocarcinoma
Disease Models, Animal Antibodies	>3 publications with C-TAK1 and Disease Models, Animal
Seizures Antibodies	>2 publications with C-TAK1 and Seizures
Weight Loss Antibodies	>2 publications with C-TAK1 and Weight Loss
Liver Diseases Antibodies	>2 publications with C-TAK1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with C-TAK1 and Carcinoma, Hepatocellular
Fatty Liver Antibodies	>1 publications with C-TAK1 and Fatty Liver
Inflammation Antibodies	>1 publications with C-TAK1 and Inflammation
Edema Antibodies	>1 publications with C-TAK1 and Edema

Organs/Tissues associated with anti-C-TAK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with C-TAK1 and Brain
Liver Antibodies	>7 publications with C-TAK1 and Liver
Blood Antibodies	>7 publications with C-TAK1 and Blood
Nerve Antibodies	>3 publications with C-TAK1 and Nerve
Kidney Antibodies	>3 publications with C-TAK1 and Kidney
Muscle Antibodies	>3 publications with C-TAK1 and Muscle
Bone Antibodies	>3 publications with C-TAK1 and Bone
Stomach Antibodies	>2 publications with C-TAK1 and Stomach
Prostate Antibodies	>2 publications with C-TAK1 and Prostate
Bladder Antibodies	>1 publications with C-TAK1 and Bladder