Rabbit Anti-CCR8 Polyclonal Antibody – Cat# MBS396066

Western blot analysis using anti-CCR8 (EL) antibody at 1 ug/ml on human spleen tissue lysates

CCR8 Antibody – Rabbit Polyclonal

Name: CCR8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS396066
Price: 720 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS396066

CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR11-4. The encoded seven transmembrane protein was identified as the receptor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CCR8 (EL) (HIV and chemokine receptor), Polyclonal Antibody

Full Product Name

CCR8 (EL) (HIV and chemokine receptor)

Product Gene Name

anti-CCR8 antibody

Product Synonym Names

C-C chemokine receptor type 8; Chemokine receptor-like 1; CDw198; GPR-Cy6

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Purity/Purification

Antigen Immunoaffiinity Purification

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

Chromosome Location

Chromosome: 3; NC_000003.11 (39371197..39375171). Location: 3p22

OMIM

601834

3D Structure

ModBase 3D Structure for P51685

Immunogen

Antibody raised against a synthetic peptide corresponding to amino acids 183 to 201 of the human CCR8. Peptide sequence is located in the second extracellular loop.

Positive Control

Human spleen tissue lysate

Product Categories/Family for anti-CCR8 antibody

Polyclonal Antibody; Chemokines & Receptors

Applications Tested/Suitable for anti-CCR8 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CCR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCR8 purchase

MBS396066 is an antibody targeting CCR8. Also known as CCR8 (EL) (HIV and chemokine receptor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR8. It may not necessarily be applicable to this product.

NCBI GI #

4885121

NCBI GeneID

1237

NCBI Accession #

NP_005192.1

UniProt Primary Accession #

P51685

UniProt Secondary Accession #

Q3KNQ8; Q9BYX5; B2RC64

UniProt Related Accession #

P51685

GenBank Nucleotide #

NM_005201.3

NCBI Official Full Name

C-C chemokine receptor type 8

NCBI Official Synonym Full Names

chemokine (C-C motif) receptor 8

NCBI Official Symbol

CCR8

NCBI Official Synonym Symbols

CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8

UniProt Protein Name

C-C chemokine receptor type 8

UniProt Synonym Protein Names

CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1

Protein Family

C-C chemokine receptor

UniProt Gene Name

CCR8

UniProt Synonym Gene Names

CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6

UniProt Entry Name

CCR8_HUMAN

NCBI Protein Information

C-C chemokine receptor type 8; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2

NCBI Summary for CCR8

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

UniProt Comments for CCR8

Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Ref.3 Ref.10 Ref.11 Ref.12

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Caution: Was originally (Ref.10) thought to be a receptor for SCYA3 and SCYA17.

Research Articles on CCR8

1. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR8 antibody

Reference Product	PubMed Publications
CCL1 antibody	>94 publications with CCR8 and CCL1
CCL17 antibody	>34 publications with CCR8 and CCL17
CCL5 antibody	>24 publications with CCR8 and CCL5
CCL4 antibody	>24 publications with CCR8 and CCL4
CXCL10 antibody	>15 publications with CCR8 and CXCL10
CXCL9 antibody	>8 publications with CCR8 and CXCL9
CCL16 antibody	>8 publications with CCR8 and CCL16
CCL20 antibody	>7 publications with CCR8 and CCL20
CXCL11 antibody	>4 publications with CCR8 and CXCL11
CCL21 antibody	>1 publications with CCR8 and CCL21

Pathways associated with anti-CCR8 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR8 antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>101 publications with CCR8 and Immune System Diseases
Inflammation Antibodies	>69 publications with CCR8 and Inflammation
Respiratory Tract Diseases Antibodies	>34 publications with CCR8 and Respiratory Tract Diseases
Lung Diseases Antibodies	>33 publications with CCR8 and Lung Diseases
Neoplasms Antibodies	>27 publications with CCR8 and Neoplasms
Disease Models, Animal Antibodies	>25 publications with CCR8 and Disease Models, Animal
Autoimmune Diseases Antibodies	>20 publications with CCR8 and Autoimmune Diseases
Necrosis Antibodies	>16 publications with CCR8 and Necrosis
Encephalomyelitis, Autoimmune, Experimental Antibodies	>6 publications with CCR8 and Encephalomyelitis, Autoimmune, Experimental
Hypersensitivity, Delayed Antibodies	>5 publications with CCR8 and Hypersensitivity, Delayed

Organs/Tissues associated with anti-CCR8 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>180 publications with CCR8 and Blood