CD38 Antibody – Mouse

Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Catalytic activity: NAD+ + H2O = ADP-ribose + nicotinamide.

Enzyme regulation: ATP inhibits the hydrolyzing activity.

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Ref.2

Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Sequence similarities: Belongs to the ADP-ribosyl cyclase family.