Rabbit Anti-HBD-1 Antibody – Cat# MBS397180

Beta-Defensin-1 (HBD-1) Antibody – Rabbit

Name: HBD-1 Antibody; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS397180
Price: 1170 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS397180

Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Beta-Defensin-1 (HBD-1), Antibody

Full Product Name

Beta-Defensin-1 (HBD-1)

Product Gene Name

anti-HBD-1 antibody

Host

Rabbit

Species Reactivity

Human, Monkey. Does not react with mouse and rat.

Form/Format

Serum lyophilized with PBS and sodium azide 0.05%

Preparation and Storage

Store at -20 degree C.

Molecular Weight

7,420 Da

3D Structure

ModBase 3D Structure for P60022

Immunogen

Synthetic peptide, 17 AA near N-terminus of the mature HBD-1, coupled to KLH for immunisation of rabbits

Positive Control

Renal epithelia, bladder epithelia

Applications Tested/Suitable for anti-HBD-1 antibody

Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), Radioimmunoassay (RIA), Western Blot (WB)

Application Notes for anti-HBD-1 antibody

WB: 1:1000-1:5000
ELISA: 1:10000-1:50000

Product References and Citations for anti-HBD-1 antibody

1. Bensch K.W., Raida M., Mägert H.J., Schulz-Knappe P., and W.G. Forssmann. HBD-1: a novel beta -defensin from human plasma. FEBS Lett 1995, 368; 331-335. (original publication HBD-1). 2. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest. 1998 Apr 15;101(8):1633-42. 3. O'Neil DA, Porter EM, Elewaut D, Anderson GM, Eckmann L, Ganz T, Kagnoff MF. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol. 1999 Dec 15;163(12):6718-24. 4. Ganz T. Defensins and host defense. Science. 1999 Oct 15;286(5439):420-1. 5. Shi J, Zhang G, Wu H, Ross C, Blecha F, Ganz T. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun. 1999 Jun;67(6):3121-7.

Other Notes

Small volumes of anti-HBD-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HBD-1 purchase

MBS397180 is an antibody targeting HBD-1. Also known as Beta-Defensin-1 (HBD-1). Reactive in Human, Monkey. Does not react with mouse and rat.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HBD-1. It may not necessarily be applicable to this product.

NCBI GI #

4885181

NCBI GeneID

1672

NCBI Accession #

NP_005209.1

UniProt Primary Accession #

P60022

UniProt Secondary Accession #

Q09753

UniProt Related Accession #

P60022

GenBank Nucleotide #

NM_005218.3

NCBI Official Full Name

beta-defensin 1 preproprotein

NCBI Official Synonym Full Names

defensin beta 1

NCBI Official Symbol

DEFB1

NCBI Official Synonym Symbols

BD1; HBD1; DEFB-1; DEFB101

UniProt Protein Name

Beta-defensin 1

UniProt Synonym Protein Names

Defensin, beta 1

UniProt Gene Name

DEFB1

UniProt Synonym Gene Names

BD1; HBD1; BD-1; hBD-1

NCBI Protein Information

beta-defensin 1

NCBI Summary for HBD-1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

UniProt Comments for HBD-1

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).

Research Articles on HBD-1

1. identification of critical promoter regions of DEFB1 that are epigenetically influenced by lactobacilli in vaginal keratinocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HBD-1 antibody

Reference Product	PubMed Publications
DEFB4A antibody	>132 publications with HBD-1 and DEFB4A
CAMP antibody	>7 publications with HBD-1 and CAMP
DEFA6 antibody	>5 publications with HBD-1 and DEFA6
DEFA5 antibody	>4 publications with HBD-1 and DEFA5
CCR6 antibody	>4 publications with HBD-1 and CCR6
DEFA4 antibody	>3 publications with HBD-1 and DEFA4

Pathways associated with anti-HBD-1 antibody

Products by Pathway	Pathway Diagram
Beta Defensins Pathway antibodies	Beta Defensins Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram

Diseases associated with anti-HBD-1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>61 publications with HBD-1 and Inflammation
Necrosis Antibodies	>34 publications with HBD-1 and Necrosis
Lung Diseases Antibodies	>32 publications with HBD-1 and Lung Diseases
Carcinoma Antibodies	>22 publications with HBD-1 and Carcinoma
Fibrosis Antibodies	>18 publications with HBD-1 and Fibrosis
Kidney Diseases Antibodies	>8 publications with HBD-1 and Kidney Diseases
Adenoma Antibodies	>4 publications with HBD-1 and Adenoma
Prostatic Neoplasms Antibodies	>4 publications with HBD-1 and Prostatic Neoplasms
Precancerous Conditions Antibodies	>3 publications with HBD-1 and Precancerous Conditions
Lung Neoplasms Antibodies	>3 publications with HBD-1 and Lung Neoplasms

Organs/Tissues associated with anti-HBD-1 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>41 publications with HBD-1 and Skin
Kidney Antibodies	>30 publications with HBD-1 and Kidney
Intestine Antibodies	>23 publications with HBD-1 and Intestine
Muscle Antibodies	>6 publications with HBD-1 and Muscle
Prostate Antibodies	>6 publications with HBD-1 and Prostate
Brain Antibodies	>5 publications with HBD-1 and Brain
Thyroid Antibodies	>2 publications with HBD-1 and Thyroid
Pancreas Antibodies	>2 publications with HBD-1 and Pancreas
Connective Tissue Antibodies	>2 publications with HBD-1 and Connective Tissue