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Elastin (ELN) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS397198

Elastin is the major protein of elastic fibres that form a randomly orientated network in many tissues. Due to its high content of hydrophobic amino acids it is relatively resistant to chemicals and proteinase. Its principal function is to provide elasticity… More details

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Product Overview

Product Name
Elastin (Eln), Antibody
Full Product Name
Elastin, rat
Product Gene Name
anti-Eln antibody
Host
Rabbit
Species Reactivity
Rat, Mouse elastin (strong), Human elastin (<0,1%)
Form/Format
Lyophilized from phosphate buffered solution; no BSA and preservative added.
Purity/Purification
Affinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C.
Molecular Weight
67,604 Da
3D Structure
ModBase 3D Structure for Q99372
Immunogen
Purified elastin from rat aorta
Positive Control
Rat skin or aorta
Incubation Time
IHC(P) 60 min at RT or 2-8 degree C over night
Pre-Treatment
After de-waxing the tissue slices they are treated with 0.2% hyaluronidase (app. 300 U/mg) in TBS 15 min at 37 degree C. There after non-specific binding is blocked by blocking serum or 3% BSA in TBS. For peroxidase systems blocking with 1% peroxide solution in TBS for 30 min at RT is recommended.
Applications Tested/Suitable for anti-Eln antibody
Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, ELISA (EIA), Radioimmunoassay (RIA)
Application Notes for anti-Eln antibody
IF: 1:40
IHC-P: 1:500
ELISA: 1:200

Product References and Citations for anti-Eln antibody

1. Desmoulière A., Darby I., Monte Alto Costa A., Raccurt M., Tuchweber B., Sommer P., Gabbiani G. (1997) Extracellular Matrix Deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. Lab Invest.76(6):765-78. 2. Lethias C., Chignier E., Garrone R., Hartmann D.J., Eloy R. (1988) Elastogenesis in rat arterial grafts: elastin deposits on microfibrillar and non-microfibrillar structures. Histochem. J. 20, 715-721. 3. Ruggiero F., Lethias C., Garrone R. (1987) Immunolabelling of freeze-fractured tissue: thin sections of rat aorta after labelling of elestic laminae. Eur. J. Cell. Biol. 44, 90-92. 4. Lethias C., Hartmann D.J., Masmejean M., Ravazzola M., Sabbagh I., Ville G., Herbage D., Eloy R. (1987) Ultrastructural immunolocalization of elastic fibers in rat blood vessels using the protein A-gold technique. J. Histochem. Cytochem. 35, 15-21.

Other Notes

Small volumes of anti-Eln antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Eln purchase

MBS397198 is an antibody targeting Eln. Also known as Elastin, rat. Reactive in Rat, Mouse elastin (strong), Human elastin (<0,1%). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Eln. It may not necessarily be applicable to this product.

NCBI GI #
55742709
NCBI GeneID
25043
NCBI Accession #
NP_036854.1
UniProt Primary Accession #
Q99372
UniProt Secondary Accession #
Q5RKH4
UniProt Related Accession #
Q99372
GenBank Nucleotide #
NM_012722.1
NCBI Official Full Name
elastin
NCBI Official Synonym Full Names
elastin
NCBI Official Symbol
Eln
NCBI Official Synonym Symbols
Trela; TREL11; Trela26; RATTREL11
UniProt Protein Name
Elastin
UniProt Synonym Protein Names
Tropoelastin
Protein Family
Elastin
UniProt Gene Name
Eln
NCBI Protein Information
elastin

NCBI Summary for Eln

precursor of elastin, which is a major component of the elastic fibers of the extracellular matrix; confers elasticity to tissues [RGD, Feb 2006]

UniProt Comments for Eln

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle ().

Research Articles on Eln

1. Overall, this study suggested that UC-MSCs could ameliorate aberrant elastin expression in the lung of hyperoxia-induced BPD model which may be associated with suppressing increased TGFbeta1 activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Eln antibody

 Reference Product  PubMed Publications
 Fbn1 antibody  >10 publications with Eln and Fbn1
 Fbln5 antibody  >7 publications with Eln and Fbln5
 Loxl1 antibody  >5 publications with Eln and Loxl1
 Lox antibody  >3 publications with Eln and Lox
 Mfap5 antibody  >2 publications with Eln and Mfap5
 Fbn2 antibody  >2 publications with Eln and Fbn2

Pathways associated with anti-Eln antibody

 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram

Diseases associated with anti-Eln antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >104 publications with Eln and Heart Diseases
 Aortic Stenosis, Supravalvular Antibodies  >76 publications with Eln and Aortic Stenosis, Supravalvular
 Williams Syndrome Antibodies  >69 publications with Eln and Williams Syndrome
 Hypertension Antibodies  >23 publications with Eln and Hypertension
 Disease Models, Animal Antibodies  >20 publications with Eln and Disease Models, Animal
 Lung Diseases Antibodies  >15 publications with Eln and Lung Diseases
 Inflammation Antibodies  >12 publications with Eln and Inflammation
 Cutis Laxa Antibodies  >11 publications with Eln and Cutis Laxa
 Hypertrophy Antibodies  >9 publications with Eln and Hypertrophy
 Lung Injury Antibodies  >8 publications with Eln and Lung Injury

Organs/Tissues associated with anti-Eln antibody

 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >59 publications with Eln and Artery
 Heart Antibodies  >57 publications with Eln and Heart
 Muscle Antibodies  >57 publications with Eln and Muscle
 Connective Tissue Antibodies  >36 publications with Eln and Connective Tissue
 Lung Antibodies  >30 publications with Eln and Lung
 Brain Antibodies  >28 publications with Eln and Brain
 Eye Antibodies  >11 publications with Eln and Eye
 Embryonic Tissue Antibodies  >8 publications with Eln and Embryonic Tissue
 Kidney Antibodies  >5 publications with Eln and Kidney
 Adipose Tissue Antibodies  >4 publications with Eln and Adipose Tissue
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