Human GM Active Protein – Cat# MBS142098

Granulocyte Macrophage-Colony Stimulating Factor (GM) Human Active Protein

Name: GM Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142098
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142098

Description: Human Factor-IX produced from fresh frozen human plasma is a glycosylated polypeptide chain having a molecular mass of 56 kDa. .Introduction: Human Factor IX also called Christmas-Factor is a glycoprotein, which is synthesized in the liver and… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Granulocyte Macrophage-Colony Stimulating Factor (GM), Active Protein

Full Product Name

Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor

Product Gene Name

GM active protein

Product Synonym Names

Coagulation factor IX, EC 3.4.21.22, Christmas factor, Plasma thromboplastin component, PTC, F9, FIX, HEMB, MGC129641, MGC129642, GLA domain, Factor IX.

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Al a-Arg-Ser. N-terminal methionine has been completely removed enzymatica lly

Form/Format

The Factor-IX was lyophilized from a sterile solution containing 20mM Tris-HCl pH-7.4, 0.1M NaCl and 1mM Benzamidine.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized Factor-IX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-IX should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Molecular Weight

16,295 Da

OMIM

138960

3D Structure

ModBase 3D Structure for P04141

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Source

Human Plasma.

Solubility

It is recommended to reconstitute the lyophilized 100U Factor-IX in sterile 100µl of 18M?-cm H2O, which can then be further diluted to other aqueous solutions.

Biological Activity

The activity per mg was tested and found to be 306.5 PEU/mg.

Human Virus Test

Human plasma was tested and found negative for HIV-1, HIV-2, Hepatitis B Surface antigen and HCV. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

Product Categories/Family for GM active protein

Cytokines and Growth Factors; Growth Factors; Colony Stimulating Factor

Other Notes

Small volumes of GM active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GM purchase

MBS142098 is an active protein targeting GM. Also known as Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor.

Additional Details

NCBI/Uniprot data below describe general gene information for GM. It may not necessarily be applicable to this product.

NCBI GI #

27437030

NCBI GeneID

1437

NCBI Accession #

NP_000749.2

UniProt Primary Accession #

P04141

UniProt Secondary Accession #

Q14CE8; Q2VPI8; Q8NFI6

UniProt Related Accession #

P04141

GenBank Nucleotide #

NM_000758.3

NCBI Official Full Name

granulocyte-macrophage colony-stimulating factor

NCBI Official Synonym Full Names

colony stimulating factor 2 (granulocyte-macrophage)

NCBI Official Symbol

CSF2

NCBI Official Synonym Symbols

GMCSF

UniProt Protein Name

Granulocyte-macrophage colony-stimulating factor

UniProt Synonym Protein Names

Colony-stimulating factor; CSF; Molgramostin; Sargramostim

Protein Family

Envelope glycoprotein

UniProt Gene Name

CSF2

UniProt Synonym Gene Names

GMCSF; GM-CSF; CSF

UniProt Entry Name

CSF2_HUMAN

NCBI Protein Information

granulocyte-macrophage colony-stimulating factor; CSF; granulocyte macrophage-colony stimulating factor; molgramostin; sargramostim

NCBI Summary for GM

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

UniProt Comments for GM

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

Research Articles on GM

1. Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-b1 treatment, and decreased the expression of E-cadherin. Our results suggest that GM-CSF could induce EMT in human HERS/ERM cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GM active protein

Reference Product	PubMed Publications
IL4 active protein	>18 publications with GM and IL4
IL3 active protein	>14 publications with GM and IL3
IL5 active protein	>10 publications with GM and IL5
CSF2RB active protein	>10 publications with GM and CSF2RB
CSF2RA active protein	>5 publications with GM and CSF2RA
STAT3 active protein	>3 publications with GM and STAT3
JAK2 active protein	>2 publications with GM and JAK2
FOS active protein	>2 publications with GM and FOS
SDC2 active protein	>1 publications with GM and SDC2

Pathways associated with GM active protein

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Calcium Signaling In The CD4+ TCR Pathway antibodies	Calcium Signaling In The CD4+ TCR Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with GM active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>41 publications with GM and Inflammation
Necrosis Antibodies	>26 publications with GM and Necrosis
Lung Diseases Antibodies	>9 publications with GM and Lung Diseases
Breast Neoplasms Antibodies	>7 publications with GM and Breast Neoplasms
Fibrosis Antibodies	>4 publications with GM and Fibrosis
Neoplasms, Experimental Antibodies	>4 publications with GM and Neoplasms, Experimental
Carcinoma Antibodies	>3 publications with GM and Carcinoma
Leukemia, Myeloid, Acute Antibodies	>3 publications with GM and Leukemia, Myeloid, Acute
Arthritis, Rheumatoid Antibodies	>3 publications with GM and Arthritis, Rheumatoid
Lung Neoplasms Antibodies	>3 publications with GM and Lung Neoplasms

Organs/Tissues associated with GM active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>43 publications with GM and Blood
Bone Antibodies	>15 publications with GM and Bone
Lung Antibodies	>12 publications with GM and Lung
Intestine Antibodies	>2 publications with GM and Intestine